Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this disease are poorly understood. Here, using single-cell transcriptomic analysis,… Continue reading XCR1+ type 1 conventional #dendritic cells drive liver pathology in non-alcoholic #steatohepatitis
Category: Hepatology
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline… Continue reading Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at… Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association… Continue reading Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe… Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease
Alcohol-associated liver disease represents a spectrum of histopathological changes from steatosis to advanced fibrosis and cirrhosis. The major goals of this retrospective study were to characterize the histologic features in patients with excessive alcohol use who presented with an abnormal hepatic panel and/or abnormal radiographic imaging and did not meet the clinical diagnosis of alcoholic… Continue reading Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease
Fructose- and sucrose- but not glucose-sweetened #beverages promote hepatic de novo #lipogenesis: A randomized controlled trial
Excessive fructose intake associates with increased de novo lipogenesis, blood triglycerides, and hepatic insulin resistance. Whether fructose-specific effects on lipid metabolism in healthy men exist independently from overfeeding needs clarification. Methods 94 subjects were studied in this double-blind, randomized trial. They were assigned to daily consumption of sugar-sweetened beverages (SSB) containing moderate amounts of fructose,… Continue reading Fructose- and sucrose- but not glucose-sweetened #beverages promote hepatic de novo #lipogenesis: A randomized controlled trial
#Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) are at increased risk of both cardiovascular disease (CVD) and advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD). Statin use is known to reduce the incidence of CVD while evidence on an effect on NAFLD severity is limited. Methods This is a cross-sectional study performed with data… Continue reading #Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Effects of two personalized #dietary strategies during a 2‐year intervention in subjects with nonalcoholic #fatty #liver disease: a randomized trial
Background and objectives Nonalcoholic fatty liver disease (NAFLD) management is focused on lifestyle modifications, but long‐term maintenance is a challenge for many individuals. This study aimed to evaluate the long‐term effects of two personalized energy‐restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight/obese subjects with NAFLD. Methods Ninety‐eight subjects from the Fatty… Continue reading Effects of two personalized #dietary strategies during a 2‐year intervention in subjects with nonalcoholic #fatty #liver disease: a randomized trial
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