The authors predicted quantitatively meaningful and statistically significant variation in dementia prevalence among persons approximately age 80 according to individuals' observed characteristics when they were about age 60.An individual's baseline cognitive abilities, health, and functional limitations are the strongest predictors of dementia, whereas parental health, family size, marital history, and demographics are the weakest ones.Having… Continue reading Identifying Early Predictors of #Cognitive Impairment and Dementia in a Large Nationally Representative U.S. Sample
Category: Environment
Gut #microbiota markers in early #childhood are linked to #farm living, pets in household and allergy
BackgroundChildren growing up on farms or with pets have a lower risk of developing allergy, which may be linked to their gut microbiota development during infancy MethodsChildren from the FARMFLORA birth cohort (N = 65), of whom 28 (43%) lived on a dairy farm and 40 (62%) had pets, provided fecal samples at intervals from… Continue reading Gut #microbiota markers in early #childhood are linked to #farm living, pets in household and allergy
Parent-child #relationship quality predicts higher subjective #well-being in adulthood across a diverse group of countries
Theoretically and empirically, parenting is closely related to the psychological health of offspring, but long-term effects and possible international differences are not well established. In a pre-registered multilevel modeling analysis using data from the Global Flourishing Study, we tested whether retrospective parent-child relationship quality predicts adult well-being in a representative sample of 202,898 adults living… Continue reading Parent-child #relationship quality predicts higher subjective #well-being in adulthood across a diverse group of countries
#Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults
Food choices during stressful periods often worsen, which can influence the impact of stress on vascular health. For instance, fat consumption impairs the recovery of endothelial function following mental stress, while flavanols have been shown to enhance recovery. This randomised, counterbalanced, double-blinded, crossover, postprandial intervention study examined whether flavanols consumed in combination with fat can… Continue reading #Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults
Comprehensive assessment of #pesticide use patterns and increased #cancer risk
Pesticides are an essential feature of modern-day agriculture that adds to the list of factors that increase cancer risk. Our study aims to comprehensively evaluate this relationship through a population-based approach that considers confounding variables such as county-specific rates of smoking, socioeconomic vulnerability, and agricultural land. We achieved our goal with the implementation of latent-class… Continue reading Comprehensive assessment of #pesticide use patterns and increased #cancer risk
Long-term exposure to residential #greenness and decreased risk of #depression and #anxiety
Residential greenness is considered a unique and potentially modifiable exposure construct to reduce physiological stress and improve human health. Here this study aims to investigate the longitudinal relationships of residential greenness with incident depression and anxiety and to explore and compare the pathways in which greenery may influence mental health. After excluding participants with depression… Continue reading Long-term exposure to residential #greenness and decreased risk of #depression and #anxiety
In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
Globaplastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals… Continue reading In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Tobacco exposure in adulthood is a well-established risk factor for type 2 diabetes (T2D), but how early-life tobacco exposure implicates in the development of T2D as well as whether this association varies by different genetic predisposition to T2D are unclear. Addressing these gaps may provide novel insights into early interventions of T2D.Hypothesis We hypothesized that tobacco… Continue reading 30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
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