BackgroundPrevious studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine the potential causal effect of dried fruit intake on type 2 diabetes by conducting a two-sample Mendelian randomization study.MethodsWe used genome-wide association study (GWAS) summary statistics for MR analysis to explore the causal association… Continue reading #Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
Category: Endocrinology
Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Background & aimsVery-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was conducted to explore the comparative short-term effects of these interventions individually, and in combination, on weight, body composition and metabolic outcomes.MethodsThirty individuals… Continue reading Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
INTRODUCTION: Divergent recommendations for periprocedural management of glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1 RA) medications rely on limited evidence. We performed a systematic review and meta-analysis to provide quantitative measures of gastric emptying relevant to mechanisms of weight loss and to periprocedural management of GLP-1 RA. We hypothesized that the magnitude of gastric emptying delay would… Continue reading Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
Strain-specific gut #microbial signatures in type 2 #diabetes identified in a cross-cohort analysis of 8,117 metagenomes
The association of gut microbial features with type 2 diabetes (T2D) has been inconsistent due in part to the complexity of this disease and variation in study design. Even in cases in which individual microbial species have been associated with T2D, mechanisms have been unable to be attributed to these associations based on specific microbial… Continue reading Strain-specific gut #microbial signatures in type 2 #diabetes identified in a cross-cohort analysis of 8,117 metagenomes
(OR02-02-24) Identification of a Novel Multi-target Bioactive Compound With Anti-#obesity and Anti-#diabetic Activities
Objectives: Insulin resistance and progressive decline in functional β-cell mass are two key factors for developing type 2 diabetes (T2D), which is largely driven by overweight and obesity, a significant obstacle for effective metabolic control in many patients with T2D. We recently found that elenolic acid (EA), a small molecule derived from olive can directly stimulate intestinal… Continue reading (OR02-02-24) Identification of a Novel Multi-target Bioactive Compound With Anti-#obesity and Anti-#diabetic Activities
Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Insulin secretion to 3 model macronutrients in 140 human islet donors is defined•Deep phenotyping and multi-omics reveal personalized nutrient-specific insulin release•A subset of donors with a unique proteome exhibits large insulin responses to lipids•Nutrient responsiveness in stem cell-derived islets is dysregulatedSummaryPopulation-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain… Continue reading Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
Impact of #lifestyle moderate-to-vigorous #physical activity timing on #glycemic control in sedentary adults with #overweight/obesity and metabolic impairments
ObjectiveModerate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA timing on daily glycemic control in sedentary adults with overweight/obesity and metabolic impairments.MethodsA total of 186 adults (50% women; age, 46.8 [SD 6.2] years) with overweight/obesity (BMI, 32.9… Continue reading Impact of #lifestyle moderate-to-vigorous #physical activity timing on #glycemic control in sedentary adults with #overweight/obesity and metabolic impairments
#Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
BACKGROUND:Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease.METHODS:This study includes 10 491 people (5185… Continue reading #Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
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