High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction… Continue reading #Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
Category: Endocrinology
#Hormone Therapy and Biological #Aging in Postmenopausal Women
Importance Menopause is associated with biological aging, and hormone therapy (HT) is associated with health outcomes in postmenopausal women.Objective To evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women as well as the potential modifying role of socioeconomic status (SES).Design, Setting, and Participants This population-based, retrospective cohort study included postmenopausal women… Continue reading #Hormone Therapy and Biological #Aging in Postmenopausal Women
#Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
Importance Lignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.Objective To prospectively investigate associations between lignan intake and T2D incidence.Design, Setting, and Participants Population-based cohort study of US men and women enrolled in the Nurses’ Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well… Continue reading #Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as… Continue reading The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
To evaluate the association between meal timing and type 2 diabetes risk in U.S. Hispanic/Latino adults.RESEARCH DESIGN AND METHODSThe Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, community-based, prospective cohort study. This study included 8,868 HCHS/SOL adults without diabetes at baseline (2008–2011) and attending the visit 2 examination (2014–2017). Energy intake and glycemic… Continue reading Energy Intake and Dietary Glycemic Load in Late Morning and Risk of Type 2 #Diabetes: The Hispanic Community #Health Study/Study of #Latinos, a Multicenter Prospective Cohort Study
Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated with a lower risk of… Continue reading Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
#Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
BackgroundPrevious studies have shown controversy about whether dried fruit intake is associated with type 2 diabetes. This study aimed to examine the potential causal effect of dried fruit intake on type 2 diabetes by conducting a two-sample Mendelian randomization study.MethodsWe used genome-wide association study (GWAS) summary statistics for MR analysis to explore the causal association… Continue reading #Dried fruit intake and lower risk of type 2 #diabetes: a two-sample mendelian randomization study
Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Background & aimsVery-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was conducted to explore the comparative short-term effects of these interventions individually, and in combination, on weight, body composition and metabolic outcomes.MethodsThirty individuals… Continue reading Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
INTRODUCTION: Divergent recommendations for periprocedural management of glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1 RA) medications rely on limited evidence. We performed a systematic review and meta-analysis to provide quantitative measures of gastric emptying relevant to mechanisms of weight loss and to periprocedural management of GLP-1 RA. We hypothesized that the magnitude of gastric emptying delay would… Continue reading Quantified Metrics of #Gastric Emptying Delay by #Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management
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