Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase… Continue reading A salt-induced kinase is required for the metabolic regulation of #sleep
Category: Endocrinology
#Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76,… Continue reading #Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women
..After 1 913 978 person-years of follow-up, 12 156 (36.6%) women were obese and 2014 (6.1%) had received a diagnosis of type 2 diabetes. Women born by cesarean delivery were more likely to be classified as obese and to have received a diagnosis of type 2 diabetes during follow-up. The multivariable-adjusted relative risk of obesity among women born… Continue reading Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women
Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
The existence of a diabetic cardiomyopathy has been postulated to explain the increased risk of heart failure (HF) in patients with diabetes mellitus; however, whether mechanisms specific to type 1 diabetes mellitus (T1DM) affect the myocardium is unclear. We have recently shown that poor glycemic control in patients with T1DM followed in the DCCT (Diabetes… Continue reading Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity
Liraglutide was superior to placebo with regard to the change from baseline in the BMI standard-deviation score at week 56 (estimated difference, −0.22; 95% confidence interval [CI], −0.37 to −0.08; P=0.002). A reduction in BMI of at least 5% was observed in 51 of 113 participants in the liraglutide group and in 20 of 105… Continue reading A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity
Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
..362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the… Continue reading Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but… Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
FDA Approves New Treatment for Adults with #Cushing’s Disease
The U.S. Food and Drug Administration today approved Isturisa (#osilodrostat) oral tablets for adults with Cushing’s disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease. Cushing’s disease is a rare disease in which the adrenal glands make too much of the cortisol hormone. Isturisa is the… Continue reading FDA Approves New Treatment for Adults with #Cushing’s Disease
Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not… Continue reading Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
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