Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets in sufficient quantities. Cryopreservation could solve islet supply chain challenges by enabling quality-controlled banking and pooling of donor islets. Unfortunately, cryopreservation has not succeeded in this objective, as it must simultaneously provide high recovery, viability, function and scalability. Here, we achieve this goal in… Continue reading Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation
Category: Endocrinology
Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
Aims/IntroductionWe aimed to study the predictive ability of visit-to-visit variability in albuminuria for changes in renal function in patients with type 2 diabetes mellitus. Materials and MethodsThe cohort study was carried out in a single medical center. In the model development cohort of 1008 subjects, we developed the albuminuria variability score (AVS) to evaluate the visit-to-visit… Continue reading Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes
The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day
Aims/hypothesisIn our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with adverse metabolic effects, and redesigning indoor lighting conditions to mimic the natural light/dark cycle more closely… Continue reading The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water
Highlights•Migration of > 400 plastic related and > 3500 dishwasher related compounds. •The dishwashing process increased the migration of plastic related compounds. •Oligomers suspected from polycaprolactone (PCL) were migrating. •Three of the identified photoinitiators have possible endocrine disrupting effects. •Diethyltoluamide (DEET) may have been formed from the plasticizer laurolactam. AbstractReusable plastic sports bottles are used… Continue reading Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water
Evaluation of Adiposity and Cognitive Function in Adults
Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association… Continue reading Evaluation of Adiposity and Cognitive Function in Adults
Adipogenic Activity of Chemicals Used in Plastic Consumer Products
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in cell and animal models. However, these well-known metabolism-disrupting chemicals (MDCs) represent only a minute fraction of all compounds found in plastics. To gain a comprehensive understanding of plastics as a source of exposure to MDCs, we characterized the chemicals present in 34 everyday… Continue reading Adipogenic Activity of Chemicals Used in Plastic Consumer Products
Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Diabetes mellitus is an independent risk factor for atrial fibrillation or atrial flutter (atrial arrythmia, AA). Additionally, some diabetes medications may influence AA incidence. The aim of this post hoc analysis was to assess the occurrence of AA during the study period in patients with type 2 diabetes treated with once weekly subcutaneous dulaglutide vs… Continue reading Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
Highlights1)Thyrotoxicosis with palpitation, and neck tenderness is the most common presentation of thyroiditis. The patients with new onset of thyrotoxicosis should be asked about history of mRNA-vaccine injection for the possible etiology. 2)mRNA vaccine induced thyroiditis could occur 10-20 days after the first dose or the second dose. 3)Management is to relieve the symptom of… Continue reading Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
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