High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable. MethodsWe tested the association of LCT genotype with milk consumption (for validation) and with… Continue reading Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
Category: Diet
#Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown. ObjectivesThe aim of this study was to explore the role of dysregulation in the AT metabolome on vascular redox signaling and cardiovascular outcomes. MethodsA screen was conducted for metabolites differentially secreted by thoracic AT… Continue reading #Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Prospective evidence on associations between diet quality indices and lung cancer risk is limited, particularly among older women. ObjectivesWe investigated associations between 4 diet quality indices [Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index 2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH)] and lung cancer incidence and mortality in the… Continue reading Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced… Continue reading Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
#Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Calcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk. ObjectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American… Continue reading #Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
#Cardiovascular symptoms affect the patterns of habitual #coffee consumption
Excessive coffee consumption can lead to unpleasant sensations such as tachycardia and heart palpitations. ObjectivesOur aim was to investigate if cardiovascular symptoms can lead to alterations in habitual patterns of coffee consumption. MethodsWe used information from up to 390,435 European ancestry participants in the UK Biobank, aged 39–73 y. Habitual coffee consumption was self-reported, and… Continue reading #Cardiovascular symptoms affect the patterns of habitual #coffee consumption
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study Method: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives,… Continue reading #Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
#Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake… Continue reading #Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to… Continue reading Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
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