Purpose: Alcohol misuse is widely accepted as an independent risk factor for a wide variety of lung diseases, such as pneumonia and acute respiratory distress syndrome. Alcohol induces changes in the regulatory mechanisms of the lung, both at a mechanical and immunological level. Understanding these changes might help discover new targets for drugs and therapeutic… Continue reading Alcohol’s Effects on the Lung and Lung Disease
Category: Diet
#Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Key PointsQuestion Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?Findings In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with… Continue reading Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting may be used as a strategy to minimise such effects. This acute randomised, counterbalanced, double-blinded, cross-over, placebo-controlled human study investigated whether intake of dietary… Continue reading Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Previous studies have highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the “relative association” to ascertain the optimal consumption strategy (including… Continue reading Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Daily #Mango Intake Improves #Glycemic and Body Composition Outcomes in Adults with #Prediabetes: A Randomized Controlled Study
Background: Prediabetes is on the rise and can progress to type 2 diabetes and related cardiometabolic complications if left untreated. Nutrition plays a critical role in blood glucose regulation, and evaluating the effects of whole foods on indices of glycemic control and body composition within individuals with prediabetes is important. This study examined whether consuming… Continue reading Daily #Mango Intake Improves #Glycemic and Body Composition Outcomes in Adults with #Prediabetes: A Randomized Controlled Study
Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Consumption of trimethylamine N‐oxide (TMAO) precursors, such as carnitine found in lean beef, raises circulating TMAO concentrations; however, a healthy dietary pattern may attenuate these effects.MethodsThis randomized, 4‐period crossover, controlled‐feeding study investigated the effects of Mediterranean‐style (MED) diets (carbohydrate 42%, protein 17%, fat 41%) with 14 (MED0.5; 0.5 oz), 71 (MED2.5; 2.5 oz), and 156… Continue reading Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
Background: The etiopathogenesis of IBD is not fully known; however, both genetic and environmental risk factors, including diet, are contributors to the disease. The present study aimed to determine the effect of dietary inflammatory potential, assessed using the Dietary Inflammatory Index (DII), on disease activity and inflammatory markers, such as IL-6, IL-1β, and IL-10, in… Continue reading Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
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