Immunocompromised children and young people are at no increased risk of severe COVID-19

Highlights•UK immunocompromised paediatric patients were at no increased risk of severe COVID-19. •Only 4/38 PCR detected infections were admitted to hospital. None had acute severe COVID-19 or died. •Increasing age and immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough and sore throat were associated with reporting SARS-CoV-2 infection. •Serology results suggest there was …

Continue reading Immunocompromised children and young people are at no increased risk of severe COVID-19

Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Determination of SARS-CoV-2 antibody responses in the context of pre-existing immunity to circulating human coronavirus (HCoV) is critical for understanding protective immunity. Here we perform a multifactorial analysis of SARS-CoV-2 and HCoV antibody responses in pre-pandemic (N = 825) and SARS-CoV-2-infected donors (N = 389) using a custom-designed multiplex ABCORA assay. ABCORA seroprofiling, when combined with computational modeling, enables …

Continue reading Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity