Insight into associations between the gut microbiome with metabolism and aging is crucial for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 individuals aged 40–93 years, we used 21 metabolic parameters to classify individuals into five clusters, termed metabolic multimorbidity clusters (MCs), that represent different metabolic subphenotypes. Compared to the cluster classified… Continue reading Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Category: Diet
Association between consumption of small #fish and all-cause #mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study
Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality.Design:We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using… Continue reading Association between consumption of small #fish and all-cause #mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study
#Sodium Intake and #Atopic Dermatitis
Question Is a higher level of sodium intake associated with risk of atopic dermatitis (AD)?Findings In this cross-sectional study of 215 832 adults from the UK Biobank cohort, a 1-g higher estimated 24-hour urine sodium excretion was associated with an 11% higher odds of AD diagnosis, 16% higher odds of active AD, and 11% higher odds of increasing… Continue reading #Sodium Intake and #Atopic Dermatitis
#Mediterranean #Diet Adherence and Risk of All-Cause #Mortality in #Women
Key PointsQuestion Is adherence to the Mediterranean diet associated with lower mortality in a US female population, and if so, what are possible biological mechanisms? Findings In this cohort study of 25 315 women followed up for 25 years, higher adherence to the Mediterranean diet was associated with a 23% reduced risk of all-cause mortality. Biomarkers of small… Continue reading #Mediterranean #Diet Adherence and Risk of All-Cause #Mortality in #Women
Adherence to the #low-fat diet pattern reduces the risk of #lung cancer in American adults aged 55 years and above: a prospective cohort study
ObjectivesThere is little evidence on the association between low-fat dietary patterns and lung cancer risk among middle-aged and older adults. To fill this gap, we comprehensively investigated the association of adherence to a low-fat diet (LFD) and intake of different fat components including saturated, monounsaturated, and polyunsaturated fatty acids with incidence of lung cancer and… Continue reading Adherence to the #low-fat diet pattern reduces the risk of #lung cancer in American adults aged 55 years and above: a prospective cohort study
Consumption of #fruits and #vegetables and its association with #sleep duration among Finnish adult population: a nationwide cross-sectional study
Introduction: Sleep and diet are crucial determinants of overall health and wellbeing, with the potential to mutually influence each other. This study examined the association between sleep duration and fruits and vegetables (FV) consumption among Finnish adults.Methods: The study analyzed data from the National FinHealth 2017 Study involving 5,043 adults aged 18 years and above. Participants reported… Continue reading Consumption of #fruits and #vegetables and its association with #sleep duration among Finnish adult population: a nationwide cross-sectional study
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health.Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led… Continue reading The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.Design Population based cohort study.Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018).Participants 74 563 women and 39 501 men with no history of… Continue reading Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
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