BackgroundRaised low-density lipoprotein cholesterol (LDL-C) in young adulthood (aged 18-39 years) is associated with atherosclerotic cardiovascular disease (ASCVD) later in life. Most young adults with elevated LDL-C do not currently receive lipid-lowering treatment. ObjectivesThis study aimed to estimate the prevalence of elevated LDL-C in ASCVD-free U.S. young adults and the cost-effectiveness of lipid-lowering strategies for… Continue reading Cost-Effectiveness of Lipid-Lowering Treatments in Young Adults
Category: Cardiology
Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types
An increasing number of myocarditis/pericarditis incidences has been reported after coronavirus disease-19 (COVID-19) vaccination in adolescents and young adults. This study was designed to investigate the incidence rate of—and risk for—myocarditis and pericarditis following COVID-19 vaccination in the United States according to age and vaccine type. This study used the Vaccine Adverse Events Reporting System… Continue reading Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types
Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
Moderate to vigorous physical activity (MVPA) is strongly associated with risk reductions of noncommunicable diseases and mortality. Cardiovascular health status may influence the benefits of MVPA. We compare the association between MVPA and incident major adverse cardiovascular events (MACE) and mortality between healthy individuals, individuals with elevated levels of cardiovascular risk factors (CVRF), and cardiovascular… Continue reading Dose–response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands
The role of different lipid measures for incident hypertension during more than 12 years follow-up: Tehran Lipid and Glucose Study
To examine the associations of different lipid measures and related indices with incident hypertension during a median follow-up of 12.89 years. Fasting levels of total cholesterol (TC), triglycerides (TG), high and low density lipoprotein cholesterol (HDL-C and LDL-C, respectively), and related indices (TC/HDL-C and TG/HDL-C) were determined in 7335 Iranian adults (men=3270) free of hypertension,… Continue reading The role of different lipid measures for incident hypertension during more than 12 years follow-up: Tehran Lipid and Glucose Study
Inequalities in Income and Education are Associated with Survival Differences after Out-of-hospital Cardiac Arrest: A Nationwide Observational Study
Despite the acknowledged importance of socioeconomic factors as regards cardiovascular-disease onset, and survival, the relationship between individual-level socioeconomic factors and survival after out-of-hospital cardiac arrest (OHCA) is not fully established. Our aim was to investigate whether socioeconomic variables are associated with 30-day survival after OHCA. Methods: We linked data from the Swedish Registry for Cardiopulmonary… Continue reading Inequalities in Income and Education are Associated with Survival Differences after Out-of-hospital Cardiac Arrest: A Nationwide Observational Study
Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study
Growing evidence suggests that poor sleep health is associated with cardiovascular risk. However, research in this area often relies upon recollection dependent questionnaires or diaries. Accelerometers provide an alternative tool for measuring sleep parameters objectively. This study examines the association between wrist-worn accelerometer-derived sleep onset timing and cardiovascular disease (CVD). Methods and resultsWe derived sleep… Continue reading Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease
Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic heart disease at an early, latent stage. Whether secondary antibiotic prophylaxis is effective in preventing progression of latent rheumatic heart disease is unknown. METHODSWe conducted a randomized, controlled trial of secondary antibiotic prophylaxis in Ugandan… Continue reading Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease
Serum Nonesterified #Fatty Acids and Incident #Stroke: The CHS
Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and trans fatty acids. Methods and ResultsCHS (Cardiovascular Health Study) participants (N=2028) who were free of stroke at baseline (1996–1997)… Continue reading Serum Nonesterified #Fatty Acids and Incident #Stroke: The CHS
Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure (HF) and death in patients with HF with reduced ejection fraction (HFrEF). Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes… Continue reading Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
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