BackgroundSome cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time using published population-based cohort studies that had used consistent methods with each wave and aimed to quantify associated changes in… Continue reading Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
Category: Cardiology
Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
Abstract: Background: We conducted a systematic review and meta-analysis to examine the effect of dietary intake of cocoa on anthropometric measurements, lipid and glycemic profiles, and blood pressure levels in adults, with and without comorbidities. Methods: The databases used were MEDLINE (PubMed), EMBASE, Web of Science, Cochrane, LILACS, and SciELO. The eligible studies were randomized… Continue reading Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
#Olfactory Impairment and the Risk of Major Adverse #Cardiovascular Outcomes in Older Adults
BackgroundOlfactory impairment is common in older adults and may be associated with adverse cardiovascular health; however, empirical evidence is sparse. We examined olfaction in relation to the risk of coronary heart disease (CHD), stroke, and congestive heart failure (CHF).Methods and ResultsThis study included 2537 older adults (aged 75.6±2.8 years) from the Health ABC (Health, Aging, and… Continue reading #Olfactory Impairment and the Risk of Major Adverse #Cardiovascular Outcomes in Older Adults
Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
Insight into associations between the gut microbiome with metabolism and aging is crucial for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 individuals aged 40–93 years, we used 21 metabolic parameters to classify individuals into five clusters, termed metabolic multimorbidity clusters (MCs), that represent different metabolic subphenotypes. Compared to the cluster classified… Continue reading Divergent age-associated and metabolism-associated gut #microbiome signatures modulate #cardiovascular disease risk
#Atherosclerotic #Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations
Key PointsQuestion How do estimates of 10-year atherosclerotic cardiovascular disease (ASCVD) risk and recommendations for primary prevention statin therapy differ between the 2023 American Heart Association (AHA) Predicting Risk of Cardiovascular Disease Events (PREVENT) equations and the 2013 AHA/American College of Cardiology pooled cohort equations (PCEs)?Findings In this cross-sectional study of 3785 adults aged 40 to 75… Continue reading #Atherosclerotic #Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations
Effect of timed dosing of usual #antihypertensives according to patient chronotype on #cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study
BackgroundTiming drug administration to endogenous circadian rhythms may enhance treatment efficacy. In the Chronotype sub-study of the Treatment in Morning versus Evening (TIME) clinical trial we examined whether timing of usual antihypertensive medications according to patient chronotype (a behavioural marker of personal circadian rhythm) may influence clinical cardiovascular outcomes.MethodsThis was a cohort sub-study of TIME,… Continue reading Effect of timed dosing of usual #antihypertensives according to patient chronotype on #cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study
#Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
The prevention of thromboembolism in atrial fibrillation (AF) is typically restricted to patients with specific risk factors and ignores outcomes such as vascular dementia. This population-based cohort study used electronic healthcare records from 5,199,994 primary care patients (UK; 2005–2020). A total of 290,525 (5.6%) had a diagnosis of AF and were aged 40–75 years, of… Continue reading #Thromboembolic events and vascular #dementia in patients with atrial #fibrillation and low apparent stroke risk
#Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Real-world data of radiofrequency catheter #ablation in paroxysmal atrial #fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry
BackgroundThe safety and long-term efficacy of radiofrequency (RF) catheter ablation (CA) of paroxysmal atrial fibrillation (PAF) has been well established. Contemporary techniques to optimize ablation delivery, reduce fluoroscopy use, and improve clinical outcomes have been developedObjectiveThe purpose of this study was to assess the contemporary real-world practice approach and long-term outcomes of RF CA for… Continue reading Real-world data of radiofrequency catheter #ablation in paroxysmal atrial #fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry
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