Several previous cross‐sectional studies suggested that body roundness index (BRI) may be associated with cardiovascular disease (CVD). However, the association should be further validated. Our study aimed to assess the association of the BRI trajectories with CVD among middle‐aged and older Chinese people in a longitudinal cohort.Methods and ResultsA total of 9935 participants from the… Continue reading Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
Category: Cardiology
#Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction… Continue reading #Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
#Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions of cardiomyocyte mitochondria, thus causing cardiac dysfunction.Methods: Through the Seahorse Mito… Continue reading #Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Low-Dose Triple-Pill vs Standard-Care Protocols for #Hypertension Treatment in NigeriaA Randomized Clinical Trial
Importance With the high burden of hypertension in sub-Saharan Africa, there is a need for effective, safe and scalable treatment strategies.Objective To compare, among Black African adults, the effectiveness and safety of a novel low-dose triple-pill protocol compared with a standard-care protocol for blood pressure lowering.Design and Setting Randomized, parallel-group, open-label, multicenter trial conducted in public hospital–based family medicine… Continue reading Low-Dose Triple-Pill vs Standard-Care Protocols for #Hypertension Treatment in NigeriaA Randomized Clinical Trial
#Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
To evaluate whether associations between sitting time and all-cause and heart disease mortality are modified by physical activity in adults with diabetes.RESEARCH DESIGN AND METHODSData came from 6,335 U.S. adults with diabetes from National Health and Nutrition Examination Survey 2007–2018 (baseline), with mortality follow-up through 2019. Sitting time and moderate to vigorous physical activity (MVPA)… Continue reading #Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
#Drone delivery of automated external #defibrillators compared with ambulance arrival in real-life suspected out-of-hospital cardiac arrests: a prospective observational study in Sweden
Background: A novel approach to improve bystander defibrillation for out-of-hospital cardiac arrests is to dispatch and deliver an automated external defibrillator (AED) directly to the suspected cardiac arrest location by drone. The aim of this study was to investigate how often a drone could deliver an AED before ambulance arrival and to measure the median time… Continue reading #Drone delivery of automated external #defibrillators compared with ambulance arrival in real-life suspected out-of-hospital cardiac arrests: a prospective observational study in Sweden
A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
Advances in mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have helped curb the coronavirus disease 2019 (COVID-19) pandemic and prevent disease onset and severity. Growing cases of vaccine-associated myocarditis (VAM) following SARS-CoV-2 immunization have been reported. Although COVID-19 VAM commonly occurs in young males after the second dose of vaccination, most cases are… Continue reading A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
#Lipidome changes due to improved dietary #fat quality inform cardiometabolic risk reduction and precision #nutrition
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in… Continue reading #Lipidome changes due to improved dietary #fat quality inform cardiometabolic risk reduction and precision #nutrition
Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS) despite oral anticoagulant (OAC) treatment. Knowledge regarding the association between OAC discontinuation and the subsequent risk of recurrent IS in patients with AF is limited.Objectives To determine the risk of recurrent IS in patients with AF receiving OAC and to evaluate the association between OAC… Continue reading Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
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