Importance Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.Objective To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.Design, Setting, and Participants … Continue reading #Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
Category: Cardiology
Leadless #pacing in young patients
Leadless pacing has been established as an effective and safe therapy. The majority of published data relates to an older population. However, this therapy may be particularly attractive for a younger (<40 years) population where the complications of transvenous devices can be enhanced. These include having leads in the vasculature for a longer period of… Continue reading Leadless #pacing in young patients
Long-term trials of #colchicine for secondary prevention of #vascular events: a meta-analysis
Background and AimsColchicine has emerged as a safe and inexpensive anti-inflammatory medication to target the residual risk of cardiovascular events in the secondary prevention of coronary artery disease. Two recently published randomized controlled trials (RCTs) investigating colchicine in the post-stroke and post-myocardial infarction (MI) populations warrant a re-evaluation of colchicine. New evidence was synthesized in… Continue reading Long-term trials of #colchicine for secondary prevention of #vascular events: a meta-analysis
Dose Response of Incidental Physical #Activity Against #Cardiovascular Events and Mortality
Few middle-aged and older adults engage in regular leisure-time exercise. Incidental physical activity (IPA) encompasses activities of daily living outside the leisure-time domain. No dose-response study is available to guide IPA-focused interventions and guidelines. We examined the associations of device-assessed IPA intensities (vigorous [VIPA], moderate [MIPA], light [LIPA]) with major adverse cardiovascular events (MACE) and… Continue reading Dose Response of Incidental Physical #Activity Against #Cardiovascular Events and Mortality
60 is the new 40: preparing for better bone #health in later life
Objective: In this study we evaluated associations between nutritional factors, including calcium supplementation, and outcomes of fracture and cardiovascular mortality. We chose to report both outcomes as an illustration of the importance of nutritional factors in midlife to heart disease as this may be more impactful for supporting behavior change strategies, particularly in men.Methods: This… Continue reading 60 is the new 40: preparing for better bone #health in later life
Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.METHODS:We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of the intestinal microbiota to the development of vascular… Continue reading Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Share onGlobal Effect of #Cardiovascular Risk Factors on Lifetime Estimates
Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear.MethodsWe harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of cardiovascular disease… Continue reading Share onGlobal Effect of #Cardiovascular Risk Factors on Lifetime Estimates
Association of Accelerometer‐Derived #Physical Activity Pattern With the Risks of All‐Cause, #Cardiovascular Disease, and Cancer Death
Current guidelines suggest engaging in a minimum of 150 minutes of moderate to vigorous physical activity (MVPA) each week to support overall health. However, the effect of concentrated versus evenly distributed physical activity (PA) on health outcomes remains uncertain. This study aims to investigate the associations of “weekend warrior” pattern, where most MVPA is completed… Continue reading Association of Accelerometer‐Derived #Physical Activity Pattern With the Risks of All‐Cause, #Cardiovascular Disease, and Cancer Death
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
