Background Children and adolescents in England were offered BNT162b2 as part of the national COVID-19 vaccine roll out from September 2021. We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.Methods With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP… Continue reading OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Category: Cardiology
#Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America
Summary of Top 10 Key Points1. Approximately 6.7 million Americans over 20 years of age have heart failure (HF), and the prevalence is expected to rise to 8.5 million Americans by 2030.2. The lifetime risk of HF has increased to 24%; approximately 1 in 4 persons will develop HF in their lifetime.3. Approximately 33% of… Continue reading #Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of… Continue reading Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
Several previous cross‐sectional studies suggested that body roundness index (BRI) may be associated with cardiovascular disease (CVD). However, the association should be further validated. Our study aimed to assess the association of the BRI trajectories with CVD among middle‐aged and older Chinese people in a longitudinal cohort.Methods and ResultsA total of 9935 participants from the… Continue reading Body #Roundness Index Trajectories and the Incidence of #Cardiovascular Disease: Evidence From the China Health and Retirement Longitudinal Study
#Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
High-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels contribute to 5-year and 10-year predictions of cardiovascular risk and represent distinct pathways for pharmacologic intervention. More information about the usefulness of these biomarkers for predicting cardiovascular risk over longer periods of time in women is needed because early-life intervention represents an important risk-reduction… Continue reading #Inflammation, #Cholesterol, #Lipoprotein(a), and 30-Year #Cardiovascular Outcomes in Women
#Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions of cardiomyocyte mitochondria, thus causing cardiac dysfunction.Methods: Through the Seahorse Mito… Continue reading #Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Low-Dose Triple-Pill vs Standard-Care Protocols for #Hypertension Treatment in NigeriaA Randomized Clinical Trial
Importance With the high burden of hypertension in sub-Saharan Africa, there is a need for effective, safe and scalable treatment strategies.Objective To compare, among Black African adults, the effectiveness and safety of a novel low-dose triple-pill protocol compared with a standard-care protocol for blood pressure lowering.Design and Setting Randomized, parallel-group, open-label, multicenter trial conducted in public hospital–based family medicine… Continue reading Low-Dose Triple-Pill vs Standard-Care Protocols for #Hypertension Treatment in NigeriaA Randomized Clinical Trial
#Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
To evaluate whether associations between sitting time and all-cause and heart disease mortality are modified by physical activity in adults with diabetes.RESEARCH DESIGN AND METHODSData came from 6,335 U.S. adults with diabetes from National Health and Nutrition Examination Survey 2007–2018 (baseline), with mortality follow-up through 2019. Sitting time and moderate to vigorous physical activity (MVPA)… Continue reading #Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
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