A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

Chinese researchers have confirmed a case of asymptomatic transmission of the new coronavirus: A 20-year-old woman from Wuhan passed it to five of her family members but never got physically sick herself.. ..A report from the Chinese Centre for Disease Control and Prevention analysed records of all of China's reported cases of the virus from… Continue reading A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

#Diet modulates brain network stability, a biomarker for brain #aging, in young adults

..One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive… Continue reading #Diet modulates brain network stability, a biomarker for brain #aging, in young adults

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing… Continue reading Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

..A total of 21 cases were included (mean age, 70 years [range, 43-92 years]; 52% male). Comorbidities were identified in 18 cases (86%), with chronic kidney disease and congestive heart failure being the most common. Initial symptoms included shortness of breath (76%), fever (52%), and cough (48%) (Table 1). The mean onset of symptoms prior… Continue reading Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity

..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but… Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity

#Alcohol Use Disorder and Risk of #Suicide in a Swedish Population-Based Cohort

..The lifetime rate of suicide during the observation period was 3.54% for women and 3.94% for men with AUD, compared with 0.29% and 0.76% of women and men, respectively, without AUD. In adjusted analyses, AUD remained robustly associated with suicide: hazard ratios across observation periods ranged from 2.61 to 128.0 among women and from 2.44… Continue reading #Alcohol Use Disorder and Risk of #Suicide in a Swedish Population-Based Cohort

Surgery versus Conservative Care for Persistent #Sciatica Lasting 4 to 12 Months

..Among the patients assigned to undergo surgery, the median time from randomization to surgery was 3.1 weeks; of the 64 patients in the nonsurgical group, 22 (34%) crossed over to undergo surgery at a median of 11 months after enrollment. At baseline, the mean score for leg-pain intensity was 7.7 in the surgical group and… Continue reading Surgery versus Conservative Care for Persistent #Sciatica Lasting 4 to 12 Months

A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19

..Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3… Continue reading A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19