AbstractIntroduction The pandemic of severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) disease 2019 (COVID-19) was declared in march 2020. Knowledge of COVID-19 pathophysiology soon provided a strong rationale for the early use of anti-inflammatory, antiplatelet and anticoagulant drugs, however the evidence was only slowly and partially incorporated into institutional guidelines. Unmet needs of COVID-19 outpatients were… Continue reading EARLY OUTPATIENT TREATMENT OF COVID-19: A RETROSPECTIVE ANALYSIS OF 392 CASES IN ITALY
Author: aledopress
Medicine and Technology enthusiast..
Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
BackgroundDietary restriction of sodium has been suggested to prevent fluid overload and adverse outcomes for patients with heart failure. We designed the Study of Dietary Intervention under 100 mmol in Heart Failure (SODIUM-HF) to test whether or not a reduction in dietary sodium reduces the incidence of future clinical events. MethodsSODIUM-HF is an international, open-label,… Continue reading Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
Use of face masks did not impact COVID-19 incidence among 10–12-year-olds in Finland
AbstractIn fall 2021 in Finland, the recommendation to use face masks in schools for pupils ages 12 years and above was in place nationwide. Some cities recommended face masks for younger pupils as well. Our aim was to compare COVID-19 incidence among 10–12-year-olds between cities with different recommendations on the use of face masks in… Continue reading Use of face masks did not impact COVID-19 incidence among 10–12-year-olds in Finland
(844.3) Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors
Drug resistant HTN (rHTN) affects around 15% to 20% of hypertensive (HTN) patients. The underlying mechanisms of resistance to treatment remain poorly understood. The majority of angiotensin-converting enzyme inhibitors (ACEi) are esters, whereby we hypothesized that select gut microbiota hydrolyze ACEi rendering lower efficacy (Figure 1A). To test this hypothesis, we investigated if and which… Continue reading (844.3) Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors
Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases
BackgroundThe 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide. To date, vaccines appear to be the only method to prevent and reduce mortality. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26.COV2-S (Janssen-Johnson&Johnson). After vaccination, local and systemic adverse effects can… Continue reading Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases
Rise in prescribing for anxiety in UK primary care between 2003 and 2018: a population-based cohort study using Clinical Practice Research Datalink
Background Little is known about trends in prescribing of anxiolytics (antidepressants, benzodiazepines, beta-blockers, anticonvulsants, and antipsychotics) for treatment of anxiety. Several changes may have affected prescribing in recent years, including changes in clinical guidance. Aim To examine trends in prescribing for anxiety in UK primary care between 2003 and 2018. Design and setting A population-based… Continue reading Rise in prescribing for anxiety in UK primary care between 2003 and 2018: a population-based cohort study using Clinical Practice Research Datalink
Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long… Continue reading Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
Noninvasive Voice Biomarker Is Associated With Incident Coronary Artery Disease Events at Follow-up
AbstractObjectiveTo evaluate the association between a preidentified voice biomarker and incident coronary artery disease (CAD) events. MethodsPatients referred for clinically indicated coronary angiography underwent a total of three 30-second voice recordings using the Vocalis Health smartphone application between January 1, 2015, and February 28, 2017. A pre-established voice biomarker was derived from each individual recording,… Continue reading Noninvasive Voice Biomarker Is Associated With Incident Coronary Artery Disease Events at Follow-up
Time Trends in Incidence of Reported Memory Concerns and Cognitive Decline: A Cohort Study in UK Primary Care
Purpose: To investigate time trends in incidence of recorded memory concerns (MC) and cognitive decline (CD) in a UK older population presenting to primary care with no prior diagnosis of dementia. To determine the risk of developing dementia in people with recorded memory concern and cognitive decline.Patients and methods: We included individuals aged 65– 99… Continue reading Time Trends in Incidence of Reported Memory Concerns and Cognitive Decline: A Cohort Study in UK Primary Care
2 Medical News 