Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multiomic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel,… Continue reading Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
Background & AimsAutoimmune hepatitis episodes have been described following SARS-CoV-2 infection and vaccination but their pathophysiology remains unclear. Here, we report the case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination and sought to identify the underlying immune correlates. The patient received first oral… Continue reading SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
Axial alignment is a critical regulator of knee osteoarthritis
Taking a load offOsteoarthritis (OA) is characterized by subchondral bone thickening in addition to cartilage degeneration. Here, Oláh et al. studied the role of joint alignment in OA development. Unloading the knee joint of a patient with OA with varus malalignment by high tibial osteotomy, which corrected axial malalignment, improved pain and cartilage microstructure and… Continue reading Axial alignment is a critical regulator of knee osteoarthritis
SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Background: Waning of protection against infection with SARS-CoV-2 conferred by 2 doses of the BNT162b2 vaccine begins shortly after inoculation and becomes substantial within four months. With that, the impact of prior infection on incident SARS-CoV-2 reinfection is unclear. Therefore, we examined the long-term protection of naturally acquired immunity (protection conferred by previous infection) compared… Continue reading SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Calorie Restriction with or without Time-Restricted Eating in Weight Loss
We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal… Continue reading Calorie Restriction with or without Time-Restricted Eating in Weight Loss
Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
... DiscussionThis case illustrates immune-mediated hepatitis secondary to the Moderna vaccine, which on inadvertent re-exposure led to worsening liver injury with deranged synthetic function. This occurred in a well man with no other medical problems. The onset of jaundice associated with the mRNA vaccine was unusually rapid. This was also illustrated in the other cases… Continue reading Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
Sodium accumulation in breast cancer predicts malignancy and treatment response
BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of… Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response
COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
BackgroundAt the beginning of the SARS-CoV-2 pandemic we stated that,given the new virus and the little-known disease it caused, in theabsence of Evidence-Based Medicine indications, patients shouldhave been treated with drugs already available, useful to counteractthe pathophysiology of the COVID-19 [1]. Recent literature hasconfirmed that this could be a successful approach, demonstratingthat an early treatment… Continue reading COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Bacteria play a suspected role in the development of several cancer types, and associations between the presence of particular bacteria and prostate cancer have been reported. ObjectiveTo provide improved characterisation of the prostate and urine microbiome and to investigate the prognostic potential of the bacteria present. Design, setting, and participantsMicrobiome profiles were interrogated in sample… Continue reading Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
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