Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

..Elevated blood pressure, classified as greater than 90% for a child’s age, sex, and height according to the 2017 American Academy of Pediatrics Clinical Practice Guidelines. The a priori hypothesis that there is a positive association between tobacco exposure and elevated blood pressure in the study population was tested. Analysis included logistic regression with adjustment for possible confounders. Subgroup and sensitivity analyses were conducted. Results … Continue reading Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

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Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation

Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn’s disease (CD) and promote intestinal inflammation. Yet, how AIEC metabolism of nutrients impacts intestinal homeostasis is poorly defined. Here, we show that AIEC encoding the large subunit of propanediol dehydratase (PduC), which facilitates the utilization of fucose fermentation product 1,2-propanediol, are increased in the microbiome of CD patients and drive AIEC-induced … Continue reading Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation

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Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

To evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States. Design Observational cohort study. Setting Nationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system. Participants All 4297 patients admitted to hospital from 1 … Continue reading Early initiation of prophylactic #anticoagulation for prevention of #coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

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Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed for widespread implementation, particularly in rural and underserved populations lacking ready access to insomnia treatment. Objective To evaluate the effectiveness of telephone CBT-I vs education-only control (EOC) in older adults with moderate to severe osteoarthritis pain. Design, Setting, and Participants This is a randomized clinical trial of 327 participants 60 … Continue reading Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

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Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)–mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized hydrogel included functional domains for cell adhesion and protease cleavage sites, sensitive to cleavage by matrix metalloproteases overexpressed after myocardial infarction (MI). The … Continue reading Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

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Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after … Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

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#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease

While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline … Continue reading #Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease

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#Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19

The seasonality of respiratory diseases has been linked, among other factors, to low outdoor absolute humidity and low indoor relative humidity, which increase evaporation of water in the mucosal lining of the respiratory tract. We demonstrate that normal breathing results in an absorption-desorption cycle inside facemasks, in which supersaturated air is absorbed by the mask fibers during expiration, followed by evaporation during inspiration of dry … Continue reading #Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19

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Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden

Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have … Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden

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Early peripheral activity alters nascent subplate circuits in the #auditory cortex

Cortical function can be shaped by sensory experience during a critical period. The onset of the critical period is thought to coincide with the onset of thalamocortical transmission to the thalamo-recipient layer 4 (L4). In early development, subplate neurons (SPNs), and not L4 neurons, are the first targets of thalamic afferents. SPNs are transiently involved in early development and are largely eliminated during development. Activation … Continue reading Early peripheral activity alters nascent subplate circuits in the #auditory cortex

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NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition

Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are critical cofactors. Here, we show that IFN signaling, present in a subset of PDAC tumors, substantially lowers NAD(H) levels through up-regulating the expression of NAD-consuming enzymes PARP9, PARP10, … Continue reading NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition

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#Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA. Methods People living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to characterize RA disease activity (DAS-28). Participants also completed questionnaires to … Continue reading #Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

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