Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study

In Parkinson’s disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid disease progression and mortality. This is often reflected by an increased drop-out rate of PD patients in longitudinal studies. Active physical behavior can impact the disease course beneficially and has an overall positive effect on health. Contrarily, sedentary behavior is associated with cognitive … Continue reading Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study

Home #Oxygen Therapy for Adults with Chronic #Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Assessment, Development and Evaluation approach was used to formulate clinical recommendations. Recommendations: The panel … Continue reading Home #Oxygen Therapy for Adults with Chronic #Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory

We assessed the impact of total and partial sleep loss on neural correlates of fear conditioning and extinction learning and recall in healthy young adults. Methods Participants (56.3% female, age 24.8±3.4) were randomized to a night of normal sleep (NS, n=48), sleep restriction (SR, n=53), or sleep deprivation (SD, n=53). All completed fear conditioning and extinction learning phases the following morning. Extinction recall was tested … Continue reading Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory

Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis

Guidelines recommend targeting preventive interventions toward older adults whose life expectancy is greater than the intervention’s time to benefit (TTB). The TTB for statin therapy is unknown To conduct a survival meta-analysis of randomized clinical trials of statins to determine the TTB for prevention of a first major adverse cardiovascular event (MACE) in adults aged 50 to 75 years.. Eight trials randomizing 65 383 adults (66.3% … Continue reading Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis

A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial

Exacerbations of COPD are one of the commonest causes of admission and readmission to hospital. The role of digital interventions to support self-management in improving outcomes is uncertain. We conducted an open, randomised controlled trial of a digital health platform application (app) in 41 COPD patients recruited following hospital admission with an acute exacerbation. Subjects were randomised to either receive usual care, including a written … Continue reading A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial

Effect of #caloric restriction with or without physical #activity on body composition and epicardial #fat in type 2 diabetic patients: a pilot randomized controlled trial

There is debate over the independent and combined effects of caloric restriction (CR) and physical activity (PA) on reduction in fat mass and in epicardial fat thickness. We compared the impact of a similar energy deficit prescription by CR or by CR combined with PA on total fat mass, epicardial fat thickness, and cardiometabolic profile in individuals with type 2 diabetes In this 16-week randomized … Continue reading Effect of #caloric restriction with or without physical #activity on body composition and epicardial #fat in type 2 diabetic patients: a pilot randomized controlled trial

A Placebo-Controlled Trial of Subcutaneous #Semaglutide in Nonalcoholic #Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in patients with NASH is not known.. ..In total, 320 patients (of whom 230 had stage F2 or F3 fibrosis) were randomly assigned to receive semaglutide at a dose of 0.1 mg (80 patients), … Continue reading A Placebo-Controlled Trial of Subcutaneous #Semaglutide in Nonalcoholic #Steatohepatitis

#Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis

The COVID‐19 infection represents a global public health emergency worldwide. Several risk factors have been associated with a poor prognosis among COVID‐19 patients. We aimed to perform a systemic review and meta‐analysis to evaluate the mortality risk in elderly patients with dementia and COVID‐19 infection.. ..A total of 233 articles were retrieved; 158 were excluded for not meeting the inclusion criteria, leaving 75 articles to … Continue reading #Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis

Polypill with or without Aspirin in Persons without #Cardiovascular Disease

..Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo monthly. We report here the outcomes for the polypill alone … Continue reading Polypill with or without Aspirin in Persons without #Cardiovascular Disease

Lower abdominal and pelvic radiation and #testicular germ cell tumor risk

Testicular germ cell tumor (TGCT) incidence has increased in recent decades along with the use and dose of diagnostic radiation. Here we examine the association between reported exposure to diagnostic radiation and TGCT risk.. ..There were 315 men with TGCT and 931 men without TGCT in our study. Compared to no exposures, risk of TGCT was significantly elevated among those reporting at least three exposures … Continue reading Lower abdominal and pelvic radiation and #testicular germ cell tumor risk

Preexisting and de novo humoral immunity to #SARS-CoV-2 in humans

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detect preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable by a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the IgG class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher … Continue reading Preexisting and de novo humoral immunity to #SARS-CoV-2 in humans