Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed “epigenetic clocks” such as… Continue reading Psychological and biological resilience modulates the effects of stress on epigenetic aging
Tag: Stress
#Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its… Continue reading #Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Urinary #Stress Hormones, #Hypertension, and Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis
Psychosocial stress is a key contributing factor to the pathogenesis of hypertension and cardiovascular disease. We examined the association of urinary stress hormone levels with incident hypertension and cardiovascular events. This prospective cohort study included 412 adults (age 48–87 years) free of hypertension from the Multi-Ethnic Study of Atherosclerosis with measurements of urinary stress hormones… Continue reading Urinary #Stress Hormones, #Hypertension, and Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis
#Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Psilocybin ameliorates stress-related behavioral deficit in mice•Psilocybin increases spine density and spine size in frontal cortical pyramidal cells•Psilocybin-evoked structural remodeling is persistent for at least 1 month•The dendritic rewiring is accompanied by elevated excitatory neurotransmission SummaryPsilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural… Continue reading #Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
#Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. In this study, we show that FK506-binding protein 51 (FKBP5) plays a critical role in fine-tuning MR:GR balance in the… Continue reading #Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy… Continue reading Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for #anxiety, #obsessive-compulsive, and #stress disorders: A 3-level network meta-analysis
Anxiety, obsessive-compulsive, and stress-related disorders frequently co-occur, and patients often present symptoms of several domains. Treatment involves the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), but data on comparative efficacy and acceptability are lacking. We aimed to compare the efficacy of SSRIs, SNRIs, and placebo in multiple symptom… Continue reading Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for #anxiety, #obsessive-compulsive, and #stress disorders: A 3-level network meta-analysis
Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study
The association between psychosocial stress and coronary heart disease (CHD) may be stronger in women than men and may differ across types of stressors. In this study, we assessed associations of psychosocial stressors, including job strain, stressful life events, and social strain with the incidence of CHD in women. Methods and Results We used longitudinal… Continue reading Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study
#Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
Mental stress has been shown to induce cardiovascular events, likely due to its negative impact on vascular function. Flavanols, plant-derived polyphenolic compounds, improve endothelial function and blood pressure (BP) in humans, however their effects during stress are not known. This study examined the effects of acute intake of cocoa flavanols on stress-induced changes on vascular… Continue reading #Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
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