#Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan … Continue reading #Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice