#Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan … Continue reading #Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

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Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels

Iodine has been suggested to protect against breast cancer, but there are no epidemiological studies on individual risk. An interesting finding is that in areas where the exposure to both selenium and iodine are high (e.g. Japan), the risk of breast cancer is lower than in areas where selenium is high and iodine low (e.g. USA), or in areas where both are low (e.g. Northern … Continue reading Serum #iodine and #breast cancer risk: A prospective nested case-control study stratified for selenium levels

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Association between Dietary #Selenium Intake and the Prevalence of #Osteoporosis: A Cross-Sectional Study

To examine the correlation between dietary selenium (Se) intake and the prevalence of osteoporosis (OP) in the general middle-aged and older population in China ..Compared with the lowest quartile, the energy intake, age, gender and body mass index (BMI)-adjusted odds ratios of OP were 0.72 (95% confidence interval CI 0.55-0.94), 0.72 (95% CI 0.51-1.01) and 0.47 (95% CI 0.31-0.73) for the second, third and fourth … Continue reading Association between Dietary #Selenium Intake and the Prevalence of #Osteoporosis: A Cross-Sectional Study

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