Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long-term DR is difficult to maintain, leading to the search for compounds that regulate metabolism and increase lifespan without reducing caloric intake. The magnitude of lifespan extension from two such compounds, rapamycin and metformin, remains inconclusive, particularly in vertebrates. Here, we conducted a meta-analysis… Continue reading #Rapamycin, Not #Metformin, Mirrors #Dietary Restriction-Driven #Lifespan Extension in Vertebrates: A Meta-Analysis
Tag: Lifespan
#Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading #Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by… Continue reading Life expectancy and years of life lost for adults with diagnosed #ADHD in the UK: matched cohort study
Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
BackgroundThe hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data.MethodsUsing a framework that combines local causal discovery algorithms with discovery of maximally predictive and compact feature sets (the “Markov boundaries” of the response)… Continue reading Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
Nutrition, longevity and disease: From molecular mechanisms to interventions
Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are maintained. Here, we analyze aging and nutrition studies in simple organisms, rodents, monkeys, and humans to link longevity to conserved growth and metabolic pathways and outline their… Continue reading Nutrition, longevity and disease: From molecular mechanisms to interventions
#Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that… Continue reading #Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Healthy #lifestyle and life #expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study
..Five low risk lifestyle factors: never smoking, body mass index 18.5-24.9, moderate to vigorous physical activity (≥30 minutes/day), moderate alcohol intake (women: 5-15 g/day; men 5-30 g/day), and a higher diet quality score (upper 40%). .. The life expectancy free of diabetes, cardiovascular diseases, and cancer at age 50 was 23.7 years (95% confidence interval… Continue reading Healthy #lifestyle and life #expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study
Regulation of #lifespan by #neural excitation and REST
..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore,… Continue reading Regulation of #lifespan by #neural excitation and REST
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