Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, including a role for brain serotonergic systems in the relationship between HFD and anxiety. Evidence suggests the gut microbiome and the serotonergic brain system together… Continue reading #High-fat diet, #microbiome-gut-brain axis signaling, and #anxiety-like behavior in male rats
Tag: Fat
Dietary #Carbohydrate and #Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
BackgroundPrevious cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.ObjectivesWe examined long-term associations of carbohydrate and fat intakes with mortality.MethodsIn this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014)… Continue reading Dietary #Carbohydrate and #Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
BackgroundPrevious cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.ObjectivesWe examined long-term associations of carbohydrate and fat intakes with mortality.MethodsIn this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014)… Continue reading Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids
SignificanceUnsaturated fatty acids are critical for maintaining membrane fluidity, cellular signaling, and lipid storage. Stearoyl-CoA desaturase (SCD) regulates the dynamics between saturated and unsaturated fatty acids. How SCD is involved in cancer cell fate decisions remains incompletely understood. Here, we leveraged transcriptomics, lipidomics, and single-cell stimulated Raman scattering microscopy to show that increased levels of… Continue reading Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids
Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide
Nitric oxide (NO) plays a critical role in acute and chronic inflammation. NO’s contributions to cancer are of particular interest due to its context-dependent bioactivities. For example, immune cells initially produce cytotoxic quantities of NO in response to the nascent tumor. However, it is believed that this fades over time and reaches a concentration that… Continue reading Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide
Biomarkers of #dairy #fat intake, incident #cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis
We aimed to investigate the association of serum pentadecanoic acid (15:0), a biomarker of dairy fat intake, with incident cardiovascular disease (CVD) and all-cause mortality in a Swedish cohort study. We also systematically reviewed studies of the association of dairy fat biomarkers (circulating or adipose tissue levels of 15:0, heptadecanoic acid [17:0], and trans-palmitoleic acid… Continue reading Biomarkers of #dairy #fat intake, incident #cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis
Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high- #fat diet – implications for daily control of #satiety
Temporal partitioning of daily food intake is crucial for survival and involves the integration of internal circadian states and external influences such as the light-dark cycle and dietary composition. These intrinsic and extrinsic factors are interdependent with misalignment of circadian rhythms promoting body weight gain, while consumption of a calorie dense diet elevates the risk… Continue reading Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high- #fat diet – implications for daily control of #satiety
High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to… Continue reading High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
#Metabolic responses to polychromatic #LED and #OLED light at night
Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue… Continue reading #Metabolic responses to polychromatic #LED and #OLED light at night
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