A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Tag: Diet
The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health.Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led… Continue reading The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary,… Continue reading #Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study… Continue reading #Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk
Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with systolic and diastolic blood pressure, and the risk of hypertension in a prospective 3-year longitudinal study in older adults… Continue reading Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
#Prebiotic #diet changes neural correlates of #food decision-making in #overweight adults: a randomised controlled within-subject cross-over trial
Objective Animal studies suggest that prebiotic, plant-derived nutrients could improve homoeostatic and hedonic brain functions through improvements in microbiome–gut–brain communication. However, little is known if these results are applicable to humans. Therefore, we tested the effects of high-dosed prebiotic fibre on reward-related food decision-making in a randomised controlled within-subject cross-over study and assayed potential microbial and… Continue reading #Prebiotic #diet changes neural correlates of #food decision-making in #overweight adults: a randomised controlled within-subject cross-over trial
Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
Background Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes.MethodsIn this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes… Continue reading Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular DiseaseA Systematic Review and Meta-analysis
MPORTANCE Plant-based diets are known to improve cardiometabolic risk in the general population, but their effects on people at high risk of cardiovascular diseases (CVDs) remain inconclusive.OBJECTIVE To assess the association of vegetarian diets with major cardiometabolic risk factors,including low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and body weight in people… Continue reading Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular DiseaseA Systematic Review and Meta-analysis
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