#Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality

Older adults are vulnerable to mistimed food intake due to health and environmental changes; characterizing meal timing may inform strategies to promote healthy aging. We investigated longitudinal trajectories of self-reported meal timing in older adults and their associations with morbidity, genetic profiles, and all-cause mortality.MethodsWe analyzed data from 2945 community-dwelling older adults from the University… Continue reading #Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality

#Breakfast energy intake and dietary quality and trajectories of #cardiometabolic risk factors in older adults

Highlights•Eating 20−30% of daily energy in breakfast links to less adiposity in older adults.•It is also related to less triglycerides and more HDL cholesterol (HDL-C).•A high-quality breakfast is linked to better adiposity, HDL-C, and kidney function.•Healthy breakfast habits relate to healthy aging by improving heart risk factors. ObjectivesNot skipping breakfast is associated with a better… Continue reading #Breakfast energy intake and dietary quality and trajectories of #cardiometabolic risk factors in older adults

Modeling sex-specific whole-body metabolic responses to #feeding and #fasting

Highlights•Sex-specific model reveals mechanisms of sexual dimorphism in glucose production.•Female model shows higher gluconeogenesis from glycerol during fasting.•TG-FFA cycle facilitates liver fat removal in females through TG secretion. AbstractMen generally favor carbohydrate metabolism, while women lean towards lipid metabolism, resulting in significant sex-based differences in energy oxidation across various metabolic states such as fasting and… Continue reading Modeling sex-specific whole-body metabolic responses to #feeding and #fasting

Impact of a Low-Carbohydrate Compared with Low-Fat Breakfast on Blood Glucose Control in Type 2 Diabetes: A Randomized Trial

BackgroundIn type 2 diabetes (T2D), consuming carbohydrates results in a rapid and large increase in blood glucose, particularly in the morning when glucose intolerance is highest.ObjectivesWe investigated if a low-carbohydrate (LC) breakfast (∼465 kcal: 25 g protein, 8 g carbohydrates, and 37 g fat) could improve glucose control in people with T2D when compared with a low-fat control (CTL) breakfast (∼450… Continue reading Impact of a Low-Carbohydrate Compared with Low-Fat Breakfast on Blood Glucose Control in Type 2 Diabetes: A Randomized Trial

Monocytes re-enter the bone marrow during fasting and alter the host response to infection

Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection

Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits

The aim of this study was to examine whether breakfast status, place and habits are associated with psychosocial behavioural problems in a nationally representative sample of young people aged 4–14 years residing in Spain. This study analysed secondary data from the Spanish National Health Survey (2017), including 3,772 Spanish children and adolescents. Breakfast status, place,… Continue reading Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits

Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock

Distribution of dietary protein across meals influences muscle hypertrophy•BCAAs are involved in hypertrophic effects of protein feeding distribution•Hypertrophic effects of protein feeding distribution require the muscle clock•Breakfast protein intake is correlated with skeletal muscle functions in older women SummaryThe meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the… Continue reading Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock

Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we monitored the metabolism of older subjects in a whole-room respiratory chamber over two separate 56-h sessions in a random crossover design. In one session, one of the 3 daily meals was presented as… Continue reading Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese

Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness ..exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study -… Continue reading Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese