Background E-cigarette use is now prevalent among adolescents and young adults, raising concerns over potential adverse long-term health effects. Although it is hypothesised that e-cigarettes promote inflammation, studies have yielded conflicting evidence. Our previous work showed that JUUL, a popular e-cigarette brand, elicited minimal lung inflammation but induced significant molecular changes in adult C57BL/6 mice.Methods… Continue reading Sex-specific alterations in pulmonary metabolic, xenobiotic and lipid signalling pathways after #e-cigarette aerosol exposure during adolescence in mice
A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
PurposePhysical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults.MethodsWe performed an… Continue reading A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
#Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
Importance Sciatica is commonly caused by herniated lumbar disc and contributes to severe pain and prolonged disability. Although acupuncture is widely used by patients with chronic sciatica, the evidence of its efficacy is scarce.Objective To investigate the efficacy and safety of acupuncture compared with sham acupuncture in patients with chronic sciatica from herniated disk.Design, Settings,… Continue reading #Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
Device-measured #stationary behaviour and #cardiovascular and orthostatic circulatory disease incidence
BackgroundPrevious studies have indicated that standing may be beneficially associated with surrogate metabolic markers, whereas more time spent sitting has an adverse association. Studies assessing the dose-response associations of standing, sitting and composite stationary behaviour time with cardiovascular disease (CVD) and orthostatic circulatory disease are scarce and show an unclear picture.ObjectiveTo examine associations of daily… Continue reading Device-measured #stationary behaviour and #cardiovascular and orthostatic circulatory disease incidence
#Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.MethodsWe enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food… Continue reading #Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
#Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public health priority and a major challenge. Cardiovascular diseases are the leading cause of death and disability in the United States and around the world. Emerging evidence… Continue reading #Cardiac Contributions to #Brain Health: A Scientific Statement From the American Heart Association
Modeling sex-specific whole-body metabolic responses to #feeding and #fasting
Highlights•Sex-specific model reveals mechanisms of sexual dimorphism in glucose production.•Female model shows higher gluconeogenesis from glycerol during fasting.•TG-FFA cycle facilitates liver fat removal in females through TG secretion. AbstractMen generally favor carbohydrate metabolism, while women lean towards lipid metabolism, resulting in significant sex-based differences in energy oxidation across various metabolic states such as fasting and… Continue reading Modeling sex-specific whole-body metabolic responses to #feeding and #fasting
#Arm Position and Blood #Pressure ReadingsThe ARMS Crossover Randomized Clinical Trial
Key PointsQuestion What is the effect of commonly used arm positions on blood pressure (BP) measurements compared to the standard, recommended position?Findings This crossover randomized clinical trial of 133 adults showed that supporting the arm on the lap overestimated systolic BP by 3.9 mm Hg and diastolic BP by 4.0 mm Hg. An unsupported arm… Continue reading #Arm Position and Blood #Pressure ReadingsThe ARMS Crossover Randomized Clinical Trial
Effects of reducing #sedentary behaviour on back pain, paraspinal muscle insulin sensitivity and muscle fat fraction and their associations: a secondary analysis of a 6-month randomised controlled trial
Objectives Sedentary behaviour (SB) is a plausible intervention target for back pain mitigation. Therefore, this study aimed to investigate the effects of a 6-month SB reduction intervention on back pain and related disability outcomes, and paraspinal muscle (ie, erector spinae and transversospinales separately) insulin sensitivity (glucose uptake, GU) and muscle fat fraction (FF).Methods Sixty-four adults… Continue reading Effects of reducing #sedentary behaviour on back pain, paraspinal muscle insulin sensitivity and muscle fat fraction and their associations: a secondary analysis of a 6-month randomised controlled trial
