Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Editor’s summaryDuring sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et… Continue reading A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in brain imaging and clinical outcomes have largely been overlooked in community cases of TBI.Objective To assess whether TBI are associated with and interact with midlife changes in… Continue reading Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as… Continue reading The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer’s disease (AD). Here, we found that dopamine and the dopamine precursor levodopa (also called l-DOPA) induced Aβ degradation in the brain. Chemogenetic approaches in mice revealed that the activation of dopamine release from ventral tegmental area (VTA) neurons… Continue reading The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Longitudinal associations between #time perspective and #life satisfaction across adulthood
Time perspective is an important predictor of well-being. How time is represented, is itself subject to developmental change. A time perspective dominated by the future is increasingly replaced by one focused on the present and past as remaining lifetime decreases. These age-related changes supposedly are associated with higher subjective well-being. Previous studies yielded heterogeneous results.… Continue reading Longitudinal associations between #time perspective and #life satisfaction across adulthood
Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
AbstractBackground: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer's disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any… Continue reading Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
Background: Nerve deactivation surgery for the treatment of migraine has evolved rapidly over the past 2 decades. Studies typically report changes in migraine frequency (attacks/month), attack duration, attack intensity, and their composite score—the Migraine Headache Index—as primary outcomes. However, the neurology literature predominantly reports migraine prophylaxis outcomes as change in monthly migraine days (MMD). The goal… Continue reading Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
Electroconvulsive therapy (ECT) is one of the most efficacious interventions for treatment-resistant depression. Despite its efficacy, ECT’s neural mechanism of action remains unknown. Although ECT has been associated with “slowing” in the electroencephalogram (EEG), how this change relates to clinical improvement is unresolved. Until now, increases in slow-frequency power have been assumed to indicate increases… Continue reading Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
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