Objective To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.Design Multicentre, double blind, randomised, placebo controlled trial.Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023.Participants 328 patients with type 2 diabetes aged 20-70 years, with body mass index >25 and diabetes duration of <6… Continue reading #Dapagliflozin plus calorie restriction for remission of type 2 #diabetes: multicentre, double blind, randomised, placebo controlled trial
Physiological Data Collected from #Wearable Devices Identify and Predict Inflammatory #Bowel Disease Flares
Wearable devices capture physiological signals non-invasively and passively. Many of these parameters have been linked to inflammatory bowel disease (IBD) activity. We evaluated the associative ability of several physiological metrics with IBD flares and how they change before the development of flare.MethodsParticipants throughout the United States answered daily disease activity surveys and wore an Apple… Continue reading Physiological Data Collected from #Wearable Devices Identify and Predict Inflammatory #Bowel Disease Flares
#Irritability and #Social Media Use in US Adults
Question Is social media use by adults associated with irritability, or being prone to anger?Findings In this survey study of 42 597 US adults, high levels of social media use, in particular frequent posting, were associated with greater irritability in cross-sectional analysis.Meaning The association between social media and irritability merits further attention, given the known associations… Continue reading #Irritability and #Social Media Use in US Adults
Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse #cartilage
Female individuals who are post-menopausal present with higher incidence of knee osteoarthritis (KOA) than male counterparts; however, the mechanisms underlying this disparity are unknown. The most commonly used preclinical models lack human-relevant menopausal phenotypes, which may contribute to our incomplete understanding of sex-specific differences in KOA pathogenesis. Here we chemically induced menopause in middle-aged (14–16… Continue reading Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse #cartilage
Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
Depression treatment responses vary widely among individuals. Identifying objective biomarkers with predictive accuracy for therapeutic outcomes can enhance treatment efficiency and avoid ineffective therapies. This study investigates whether functional near-infrared spectroscopy (fNIRS) and clinical assessment information can predict treatment response in major depressive disorder (MDD) through machine-learning techniques. Seventy patients with MDD were included in… Continue reading Application of functional near-infrared spectroscopy and #machine learning to predict treatment response after six months in major #depressive disorder
Gut #microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little is known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences in diet pattern (omnivore, vegetarian and vegan) are reflected in gut microbiomes. Microbial profiles distinguished… Continue reading Gut #microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
The Neurologist’s Role in Promoting #Brain Health
Neurologic conditions are a leading cause of morbidity and mortality within the United States and worldwide. Brain health is a global concern, and the American Academy of Neurology's Brain Health Initiative promises to drive progress in this field over the next decades. Neurologists with detailed training and insight into brain function are uniquely positioned to… Continue reading The Neurologist’s Role in Promoting #Brain Health
The Association of Regular #Dog Walking with Mobility, #Falls and Fear of Falling in Later Life
BackgroundIt has been suggested that dog walking may protect against falls and mobility problems in later life, but little work to date has examined this.The aim of this study was to assess if regular dog walking was associated with reduced likelihood of falls, fear of falling and mobility problems in a large cohort of community-dwelling… Continue reading The Association of Regular #Dog Walking with Mobility, #Falls and Fear of Falling in Later Life
The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation—a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII)… Continue reading The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
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