Body #mass index, #diabetes, and the risk of #Parkinson’s disease

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..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93)… Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease

#Influenza #vaccine effectiveness 2019-2020 interim estimates

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Annual vaccination against seasonal influenza is recommended for all U.S. persons aged ≥6 months. Effectiveness of seasonal influenza vaccine varies by season. What is added by this report? According to data from the U.S. Influenza Vaccine Effectiveness Network on 4,112 children and adults with acute respiratory illness during October 23, 2019–January 25, 2020, the overall… Continue reading #Influenza #vaccine effectiveness 2019-2020 interim estimates

Empirical Anti-#MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for #Pneumonia

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..Compared with standard therapy alone, in weighted propensity score analysis, empirical anti-MRSA therapy plus standard therapy was significantly associated with an increased adjusted risk of death (adjusted risk ratio [aRR], 1.4 [95% CI, 1.3-1.5]), kidney injury (aRR, 1.4 [95% CI, 1.3-1.5]), and secondary C difficile infections (aRR, 1.6 [95% CI, 1.3-1.9]), vancomycin-resistant Enterococcus spp infections… Continue reading Empirical Anti-#MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for #Pneumonia

Body #height in young adult men and risk of #dementia later in adult life

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... A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial… Continue reading Body #height in young adult men and risk of #dementia later in adult life

Association of #Depression, #Anxiety, and Trauma With #Cannabis Use During Pregnancy

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..Depression, anxiety, and trauma diagnoses and symptoms were associated with higher odds of cannabis use among pregnant women in California. These results support previous qualitative findings that pregnant women self-report using cannabis to manage mood and stress and suggest a dose-response association, with higher odds of cannabis use associated with co-occurring depressive and anxiety disorders… Continue reading Association of #Depression, #Anxiety, and Trauma With #Cannabis Use During Pregnancy

Adverse Effects of Low-Dose #Methotrexate: A Randomized Trial

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Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis.. Random allocation to LD-MTX (≤20 mg/wk) or placebo. All participants received folic acid, 1 mg/d, 6 days per week.. ..The relative hazards of gastrointestinal (HR, 1.91 [CI, 1.75 to 2.10]), pulmonary (HR,… Continue reading Adverse Effects of Low-Dose #Methotrexate: A Randomized Trial

#Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

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..Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was… Continue reading #Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

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We have shown that combination treatment with decaffeinated green tea extract (GTE) and voluntary exercise (Ex) reduces obesity and insulin resistance in high-fat (HF)-fed mice to a greater extent than either treatment alone. Here, we investigated the effects of GTE-, Ex- or the combination on the development of obesity-related NAFLD.. ..Combination treated, but not singly… Continue reading Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise