The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible… Continue reading Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis
New Therapy Reduces Chronic Low Back Pain in Large International Study
A new study hasfound that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid… Continue reading New Therapy Reduces Chronic Low Back Pain in Large International Study
Association of Azithromycin Use With Cardiovascular Mortality
Azithromycin is one of the most commonly prescribed antibiotics in the US. It has been associated with an increased risk of cardiovascular death in some observational studies.. ..The study included 7 824 681 antibiotic exposures, including 1 736 976 azithromycin exposures (22.2%) and 6 087 705 amoxicillin exposures (77.8%), among 2 929 008 unique individuals (mean [SD] age, 50.7 [12.3] years; 1 810 127 [61.8%]… Continue reading Association of Azithromycin Use With Cardiovascular Mortality
#Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review
Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted.. Forty-two studies were included. We found a significant association of acne vulgaris with depression ( r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety ( r = 0.25 [95% confidence… Continue reading #Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review
Prevalence of Asymptomatic SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease 2019 (COVID-19) were observed in December 2019 in Wuhan, China. It has been suspected that infected persons who remain asymptomatic play a significant role in the ongoing pandemic, but their relative number and effect have… Continue reading Prevalence of Asymptomatic SARS-CoV-2 Infection
Antihypertensive Treatment in Elderly Frail Patients Evidence From a Large Italian Database
Aim of our study was to assess the relationship between adherence with antihypertensive drugs and the risk of death in frail versus nonfrail old individuals. Using the database of the Lombardy Region (Italy), we identified 1 283 602 residents aged ≥65 years (mean age 76) who had ≥3 prescriptions of antihypertensive drugs between 2011 and… Continue reading Antihypertensive Treatment in Elderly Frail Patients Evidence From a Large Italian Database
FDA Permits Marketing of First Game-Based Digital Therapeutic to Improve Attention Function in Children with ADHD
Today, the U.S. Food and Drug Administration (FDA) permitted marketing of the first game-based digital therapeutic device to improve attention function in children with attention deficit hyperactivity disorder (ADHD). The prescription-only game-based device, called EndeavorRx, is indicated for pediatric patients ages 8 to12 years old with primarily inattentive or combined-type ADHD who have demonstrated an… Continue reading FDA Permits Marketing of First Game-Based Digital Therapeutic to Improve Attention Function in Children with ADHD
Association of Living in a Food Desert With Pregnancy Morbidity
To evaluate whether women living in areas deemed food deserts had higher rates of pregnancy morbidity, specifically preeclampsia, gestational hypertension, gestational diabetes, prelabor rupture of membranes, preterm labor, than women who did not live in food deserts at the time of their pregnancy and delivery.. This was a retrospective observational study in which we reviewed… Continue reading Association of Living in a Food Desert With Pregnancy Morbidity
Association of Normal Systolic Blood Pressure Level With Cardiovascular Disease in the Absence of Risk Factors
The risk of atherosclerotic cardiovascular disease (ASCVD) at currently defined normal systolic blood pressure (SBP) levels in persons without ASCVD risk factors based on current definitions is not well defined.. Of the 1457 participants, 894 were women (61.4%); mean (SD) age was 58.1 (9.8) years and mean (SD) follow-up was 14.5 (3.9) years. There was… Continue reading Association of Normal Systolic Blood Pressure Level With Cardiovascular Disease in the Absence of Risk Factors
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