Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For… Continue reading 6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records
#Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
Although food marketing is often accused of increasing population obesity, the relationship between individual responsiveness to marketing and obesity has yet to be established: Are people with obesity more responsive to food marketing and, if so, is it a stable trait or can it be reversed by bariatric surgery? We studied the responses to three… Continue reading #Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition
The purpose of this study was to clarify the association between self‐reported night sleep duration and cognitive functions such as word memory, story memory, attention, executive function, and processing speed of older adults with normal global cognitive function. Methods A total of 241 functionally independent older adults (mean age, 75.5 ± 6.4 years) participated in… Continue reading Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition
Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial
Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older… Continue reading Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial
#Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
Mental stress has been shown to induce cardiovascular events, likely due to its negative impact on vascular function. Flavanols, plant-derived polyphenolic compounds, improve endothelial function and blood pressure (BP) in humans, however their effects during stress are not known. This study examined the effects of acute intake of cocoa flavanols on stress-induced changes on vascular… Continue reading #Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
#Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that… Continue reading #Selenium supplementation inhibits #IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice
#Sotatercept for the Treatment of Pulmonary Arterial #Hypertension
Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. Dysfunctional bone morphogenetic protein pathway signaling is associated with both hereditary and idiopathic subtypes. Sotatercept, a novel fusion protein, binds activins and growth differentiation factors in the attempt to restore balance between growth-promoting and growth-inhibiting signaling pathways. METHODS In this… Continue reading #Sotatercept for the Treatment of Pulmonary Arterial #Hypertension
Association of Vitamin #D Levels, Race/Ethnicity, and Clinical Characteristics With #COVID-19 Test Results
Deficient (ie, <20 ng/mL) or insufficient (ie, 20 to <30 ng/mL) 25-hydroxyvitamin D (also known as calcifediol) levels are more common in Black individuals than White individuals and are associated with increased coronavirus disease 2019 (COVID-19) risk. Whether COVID-19 risk is associated with differences in vitamin D levels of 30 ng/mL or greater is not… Continue reading Association of Vitamin #D Levels, Race/Ethnicity, and Clinical Characteristics With #COVID-19 Test Results
Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
Antimicrobial overuse is a major health care issue that contributes to antibiotic resistance. Such overuse includes unnecessarily long durations of antibiotic therapy in patients with common bacterial infections, such as acute bronchitis with chronic obstructive pulmonary disease (COPD) exacerbation, community-acquired pneumonia (CAP), urinary tract infections (UTIs), and cellulitis. This article describes best practices for prescribing… Continue reading Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
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