Highglights• So far, vaccines to prevent SARS-CoV-2 infection appear as promising approach for curbing the pandemic. • Vaccines for SARS-CoV-2 are being developed using several different platforms. • Some concerns have been raised regarding the safety of SARS-CoV-2 vaccines on the basis of rare adverse reactions, particularly thromboembolic. • The applicability to the real life… Continue reading SARS-CoV-2 vaccines: Lights and shadows
Quantified integrated hepatitis B virus is related to viral activity in chronic hepatitis B patients
AbstractBackground & AimsThe hepatitis B virus (HBV) can integrate in the host genome of the hepatocyte and recent findings suggest that integrated HBV contributes to the persistent production of viral proteins. Here we quantified the levels of integrated HBV in chronic hepatitis B (CHB) patients, and analysed the relation between HBV integration, virological activity (plasma… Continue reading Quantified integrated hepatitis B virus is related to viral activity in chronic hepatitis B patients
School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review
In response to the coronavirus disease 2019 (COVID-19) pandemic, 107 countries had implemented national school closures by March 18, 2020. It is unknown whether school measures are effective in coronavirus outbreaks (eg, due to severe acute respiratory syndrome [SARS], Middle East respiratory syndrome, or COVID-19). We undertook a systematic review by searching three electronic databases… Continue reading School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review
Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease
AbstractBackground & AimsSerum 25-hydroxyvitamin D (S-25(OH)D) and nonalcoholic fatty liver disease (NAFLD) are correlated in many observational studies, whereas the causality of this association is uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to determine the association between S-25(OH)D and NAFLD. MethodsSeven and six independent genetic variants associated with S-25(OH)D and… Continue reading Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease
Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown
Highlights•The COVID-19 pandemic and lockdown may have a negative impact on the mental health of adolescents. •Epidemics and disasters are associated with adolescent Post Traumatic Stress, Depression, and Anxiety symptoms. •Healthcare system adaptations are necessary for mental health support despite the lockdown. •Home confinement may be associated with increased intrafamilial violence. •Data is scarce on… Continue reading Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown
Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19
As of December 28, 2021, approximately 27% of the US population was unvaccinated against SARS-CoV-2,1 yet the prevalence of natural immunity remains unknown. Blood donor studies may have selection bias and lack clinical information.2 Previous COVID-19 infection is a possible surrogate for natural immunity, but 1 study suggested that 36% of COVID-recovered individuals are serologic… Continue reading Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19
Evaluation of Adiposity and Cognitive Function in Adults
Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association… Continue reading Evaluation of Adiposity and Cognitive Function in Adults
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. ParticipantsThe records of individuals… Continue reading Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
Seborrheic dermatitis (SD) is a common chronic inflammatory dermatosis. Current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Ketoconazole is commonly used for the treatment of SD. However, there remains limited data focusing on the effects of ketoconazole on shaping the skin microbiome in patients with SD. ObjectiveIn… Continue reading Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
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