Importance Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited.Objective To determine the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.Design, Setting, and Participants A retrospective cohort study was conducted using electronic health record… Continue reading #Nicotinamide for #Skin #Cancer Chemoprevention
Category: supplements
Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
This study aimed to investigate the association between dietary vitamin K intake and all-cause mortality in individuals with non-alcoholic fatty liver disease (NAFLD). We analyzed data from 7857 NAFLD participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018) linked to mortality outcomes from the National Death Index (NDI). Dietary vitamin K intake was… Continue reading Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
#Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
Background/Objectives: Depression is a major global health burden, and previous studies suggest that nutrient deficiencies may contribute to its development. However, research on mineral intake and depression, particularly sodium and potassium, is limited. We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey in Korea (KNHANES) and the United States… Continue reading #Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Limited studies suggest that vitamin D or omega 3 fatty acids (n–3 FAs) supplementation may be beneficial for telomere maintenance; however, evidence from large randomized clinical trials is lacking. We hypothesized that vitamin D or n–3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL)… Continue reading Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
#Exercise without Weight Loss Prevents Seasonal Decline in Vitamin #D Metabolites: The VitaDEx Randomized Controlled Trial
Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of… Continue reading #Exercise without Weight Loss Prevents Seasonal Decline in Vitamin #D Metabolites: The VitaDEx Randomized Controlled Trial
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
#Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Question Does the use of a reduced-sodium, added-potassium salt substitute vs regular salt decrease the risk of stroke recurrence and death in patients with a history of stroke?Findings In this prespecified subgroup analysis of the Salt Substitute and Stroke Study (SSaSS) trial involving 15 249 patients with stroke, the use of a salt substitute led… Continue reading Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per… Continue reading Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
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