Hypertension is the leading cause of cardiovascular disease and premature death worldwide. Owing to the widespread use of antihypertensive medications, global mean blood pressure (BP) has remained constant or has decreased slightly over the past four decades. By contrast, the prevalence of hypertension has increased, especially in low- and middle-income countries (LMICs). Estimates suggest that… Continue reading The global epidemiology of #hypertension
Category: Sports
#Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Very few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident dementia. This cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and… Continue reading #Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body… Continue reading Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
Association of #Sedentary Time and Incident Heart #Failure Hospitalization in Postmenopausal Women
Background: The 2018 US Physical Activity Guidelines recommend reducing sedentary behavior (SB) for cardiovascular health. SB’s role in heart failure (HF) is unclear. Methods: We studied 80 982 women in the Women’s Health Initiative Observational Study, aged 50 to 79 years, who were without known HF and reported ability to walk ≥1 block unassisted at… Continue reading Association of #Sedentary Time and Incident Heart #Failure Hospitalization in Postmenopausal Women
#Walking Volume and Speed Are Inversely Associated With Incidence of Treated #Hypertension in #Postmenopausal Women
Few studies have evaluated hypertension incidence in relation to walking, which is a common physical activity among adults. We examined the association between walking and hypertension incidence in 83 435 postmenopausal women who at baseline were aged 50 to 79 years, without known hypertension, heart failure, coronary heart disease, or stroke, and reported the ability to… Continue reading #Walking Volume and Speed Are Inversely Associated With Incidence of Treated #Hypertension in #Postmenopausal Women
World Health Organization 2020 guidelines on physical #activity and #sedentary behaviour
..The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake 150–300 min of moderate-intensity, or 75–150 min of vigorous-intensity physical activity, or some equivalent combination of moderate-intensity and vigorous-intensity aerobic physical activity, per week. Among children… Continue reading World Health Organization 2020 guidelines on physical #activity and #sedentary behaviour
Metabolic Architecture of Acute #Exercise Response in Middle-Aged Adults in the Community
Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.. ..We observed changes in circulating levels for 502 of 588 measured metabolites from rest… Continue reading Metabolic Architecture of Acute #Exercise Response in Middle-Aged Adults in the Community
Individual and combined associations between cardiorespiratory #fitness and grip strength with common #mental disorders: a prospective cohort study in the UK Biobank
Depression and anxiety are common mental disorders that increase physical health risks and are leading causes of global disability. Several forms of physical fitness could be modifiable risk factors for common mental disorders in the population. We examined associations between individual and combined markers of cardiorespiratory fitness and grip strength with the incidence of common… Continue reading Individual and combined associations between cardiorespiratory #fitness and grip strength with common #mental disorders: a prospective cohort study in the UK Biobank
Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study
In Parkinson's disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid disease progression and mortality. This is often reflected by an increased drop-out rate of PD patients in longitudinal studies. Active physical behavior can impact the disease course beneficially and has an overall positive… Continue reading Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study
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