..The mean (SD) age of trial participants was 69 (5.4) years and 40 617 (42.2%) were women. The mean systolic baseline blood pressure was 154 (14.9) mm Hg and the mean diastolic blood pressure was 83.3 (9.9) mm Hg. The mean duration of follow-up was 49.2 months. Blood pressure lowering with antihypertensive agents compared with… Continue reading Association of Blood Pressure Lowering With Incident #Dementia or Cognitive Impairment A Systematic Review and Meta-analysis
Category: Neurology
Effect of Cerebrovascular and/or Peripheral #Artery Disease With or Without Attainment of #Lipid Goals on Long-term Outcomes in Patients With Coronary Artery Disease
Involvement of atherosclerosis in extracardiac vascular territories may identify coronary artery disease (CAD) patients at higher risk for adverse events. We investigated the long-term prognostic implications of polyvascular disease in patients with CAD, and further analyzed lipid goal attainment and its relation to patient outcomes. The study was a retrospective analysis of 10,297 patients undergoing… Continue reading Effect of Cerebrovascular and/or Peripheral #Artery Disease With or Without Attainment of #Lipid Goals on Long-term Outcomes in Patients With Coronary Artery Disease
Heart–brain interactions shape somatosensory perception and evoked potentials
Our brain continuously receives signals from the body and the environment. Although we are mostly unaware of internal bodily processes, such as our heartbeats, they can affect our perception. Here, we show two distinct ways in which the heartbeat modulates conscious perception. First, increased heartbeat-evoked neural activity before stimulation is followed by decreased somatosensory detection.… Continue reading Heart–brain interactions shape somatosensory perception and evoked potentials
Neuroinflammation in Alzheimer’s Disease: Friend or Foe?
Neuroinflammation is part of the complex immune response within the central nervous system (CNS), whose details have been partially elucidated. The CNS immune response involves elements carried from the periphery and resident elements, mainly represented by glial cells. These cells drive neuroinflammation, which can be roughly defined as an articulated physiological response characterized by the… Continue reading Neuroinflammation in Alzheimer’s Disease: Friend or Foe?
Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway
..SIGNIFICANCE STATEMENT Astrocytes play important roles in synaptic transmission by extending fine processes around synapses. In this study, we showed that a single exposure to an acute stress triggered a retraction of lateral/fine processes in mouse cerebellar astrocytes. These astrocytes express GluA1, a glutamate receptor subunit known to lengthen astrocyte processes. We showed that astrocytic… Continue reading Emotional #Stress Induces Structural Plasticity in Bergmann Glial Cells via an AC5–CPEB3–GluA1 Pathway
Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.
During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The… Continue reading Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.
Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2
The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.. ..Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone… Continue reading Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2
A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors
In recent years a number of studies have reported the significant relationship between metabolic syndrome and neurodegenerative disease. There is accumulating evidence that the interplay of combined genetic and environmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes may be advocated for to explain the pandemic of neurodegenerative diseases.… Continue reading A 2-year Double-Blind RCT Follow-up Study with Fermented #Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered #Neurodegenerative Disease-Risk Factors
Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study
After diagnosis of a health condition, information about survival and potential transition from community into institutional care can be helpful for patients and care providers. We sought to describe the association between a new diagnosis of dementia and risk of admission to a long-term care home and death at 5 years.. ..age ≥ 90 yr;… Continue reading Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study
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