In a cross-sectional study between June 2017 and December 2018, patients with primary headache were divided into 2 groups: smartphone users (SUs) and non-smartphone users (NSUs). A questionnaire was administered for headache characteristics and treatment taken. The primary objective was to determine the association of smartphone use with new-onset headache or increase severity. The secondary… Continue reading Smartphone use and primary #headache A cross-sectional hospital-based study
Category: Neurology
Reversing a model of #Parkinson’s disease with in situ converted nigral neurons
Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here we… Continue reading Reversing a model of #Parkinson’s disease with in situ converted nigral neurons
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.. ..Overall incidence of dementia among patients with IBD was significantly… Continue reading Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Healthy #lifestyle and the risk of #Alzheimer dementia
Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet.. ..During a median follow-up of 5.8 years… Continue reading Healthy #lifestyle and the risk of #Alzheimer dementia
Detection of Ciprofloxacin resistant beta lactamase producing Neisseria meningitidis
What is already known about this topic? Most Neisseria meningitidis isolates in the United States have been susceptible to antibiotics recommended for treatment and prophylaxis. What is added by this report? During 2019–2020, 11 meningococcal isolates from U.S. patients had isolates containing a blaROB-1 β-lactamase gene associated with penicillin resistance and mutations associated with ciprofloxacin… Continue reading Detection of Ciprofloxacin resistant beta lactamase producing Neisseria meningitidis
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal homeostasis have been implicated in CA pathogenesis, and pilot study had suggested potential microbiome differences between non-CA and CA individuals based on 16S rRNA gene sequencing. We here assess microbiome differences in a larger… Continue reading Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
Repetitive negative #thinking is associated with #amyloid, tau, and cognitive decline
The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer's disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety and depression symptoms. ..RNT was associated with decline in global cognition (P =… Continue reading Repetitive negative #thinking is associated with #amyloid, tau, and cognitive decline
Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study
Epilepsy is one of the most common neurological disorders . Many individuals continue to have seizures despite medical and surgical treatments, suggesting adjunctive management strategies are required. Promising effects of daily listening to Mozart on reducing seizure frequency in individuals with epilepsy have been demonstrated over the last 20 years, but not in a rigorously… Continue reading Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study
Atrial Cardiopathy in the Absence of Atrial Fibrillation Increases Risk of Ischemic Stroke, Incident Atrial Fibrillation, and Mortality and Improves Stroke Risk Prediction
Atrial fibrillation (AF) is a major, often undetected, cardiac cause of stroke. Markers of atrial cardiopathy, including left atrial enlargement (LAE) or excessive atrial ectopy (EAE) increase the risk of AF and have shown associations with stroke. We sought to determine whether these markers improve stroke risk prediction beyond traditional vascular risk factors (eg CHA2DS2‐VASc… Continue reading Atrial Cardiopathy in the Absence of Atrial Fibrillation Increases Risk of Ischemic Stroke, Incident Atrial Fibrillation, and Mortality and Improves Stroke Risk Prediction
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