Background Impairments in inhibitory control and its underlying brain networks (control/salience areas) are associated with substance misuse. Research often assumes a causal substance exposure effect on brain structure. This assumption remains largely untested and other factors (e.g., familial risk) may confound exposure effects. We leveraged a genetically-informative sample of 24-year-old twins and a quasi-experimental cotwin… Continue reading The effects of #alcohol and #cannabis use on the cortical thickness of #cognitive control and salience brain networks in emerging adulthood: a cotwin control study
Category: Neurology
State-dependent responses to intracranial brain stimulation in a patient with #depression
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in… Continue reading State-dependent responses to intracranial brain stimulation in a patient with #depression
6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study
The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.. ..In total, 1733 of 2469 discharged patients with COVID-19 were enrolled after 736 were… Continue reading 6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study
Clinical Outcomes Associated With Left #Atrial Appendage Occlusion Versus Direct Oral #Anticoagulation in Atrial #Fibrillation
This study sought to investigate clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulants (DOACs) in patients with high-risk atrial fibrillation (AF).. ..Patients with AF enrolled in the Amulet Observational Registry (n = 1,088) who had successful LAAO with the Amplatzer Amulet device (n = 1,078) were compared with a propensity… Continue reading Clinical Outcomes Associated With Left #Atrial Appendage Occlusion Versus Direct Oral #Anticoagulation in Atrial #Fibrillation
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer's Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males,… Continue reading #Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea
The long‐term incidence of acute myocardial infarction (AMI) in patients with acute ischemic stroke (AIS) has not been well defined in large cohort studies of various race‐ethnic groups. A prospective cohort of patients with AIS who were registered in a multicenter nationwide stroke registry (CRCS‐K [Clinical Research Collaboration for Stroke in Korea] registry) was followed… Continue reading Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea
BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only… Continue reading BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury
Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of acute IS patients with high-grade CAS. Methods: From January 1, 2007,… Continue reading Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control… Continue reading Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
2 Medical News 