Importance The magnitude of cognitive change after incident myocardial infarction (MI) is unclear.Objective To assess whether incident MI is associated with changes in cognitive function after adjusting for pre-MI cognitive trajectories.Design, Setting, and Participants This cohort study included adults without MI, dementia, or stroke and with complete covariates from the following US population-based cohort studies conducted from 1971… Continue reading Association Between Acute Myocardial Infarction and Cognition
Category: Neurology
The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial
Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive blood pressure lowering and management algorithms for hyperglycaemia, pyrexia, and abnormal anticoagulation, implemented in a hospital setting, could improve outcomes for patients with acute spontaneous… Continue reading The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial
Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood
Background and ObjectivesVascular theories of cognitive aging have focused on macrovascular changes and cognitive decline. However, according to the artery-size hypothesis, microvascular changes, such as those that underlie changes in erectile function, may also play an important role in contributing to cognitive decline. Thus, we examined associations between erectile function, sexual satisfaction, and cognition starting… Continue reading Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease
Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment.Objective To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in… Continue reading Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease
Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and habitual flavanol consumption
Dietary flavanols are food constituents found in certain fruits and vegetables that have been linked to cognitive aging. Previous studies suggested that consumption of dietary flavanols might specifically be linked to the hippocampal-dependent memory component of cognitive aging and that memory benefits of a flavanol intervention might depend on habitual diet quality. Here, we tested… Continue reading Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and habitual flavanol consumption
Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear.METHODSWe performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a… Continue reading Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
Emotional sounds in space: asymmetrical representation within early-stage auditory areas
Evidence from behavioral studies suggests that the spatial origin of sounds may influence the perception of emotional valence. Using 7T fMRI we have investigated the impact of the categories of sound (vocalizations; non-vocalizations), emotional valence (positive, neutral, negative) and spatial origin (left, center, right) on the encoding in early-stage auditory areas and in the voice… Continue reading Emotional sounds in space: asymmetrical representation within early-stage auditory areas
AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults
BackgroundBody composition data have been limited to adults with disease or older age. The prognostic impact in otherwise asymptomatic adults is unclear.PurposeTo use artificial intelligence–based body composition metrics from routine abdominal CT scans in asymptomatic adults to clarify the association between obesity, liver steatosis, myopenia, and myosteatosis and the risk of mortality. Materials and MethodsIn… Continue reading AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults
Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions… Continue reading Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
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