Objective To test the hypothesis that higher level of cognitive activity predicts older age at dementia onset in Alzheimer disease (AD) dementia.Methods As part of a longitudinal cohort study, 1,903 older persons without dementia at enrollment reported their frequency of participation in cognitively stimulating activities. They had annual clinical evaluations to diagnose dementia and AD, and the… Continue reading Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia
Category: Neurology
The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Highlights•This is the first study to investigate the mediation effect of GMV on the association between HbA1c and depression.•Hba1c was negatively associated with GMV, and that association were stronger in prediabetic participants.•Cerebral GMV plays a mediating role on the association “HbA1c-depression”, with a proportions of 6.82%.•Effective control of glycemia can potentially prevent brain abnormality and… Continue reading The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
Highlights•Diet-induced NAFLD and associated systemic alterations result in behavioural changes and low-grade brain tissue hypoxia.•Brain hypoxia is likely linked to the induced low-grade brain inflammation, as well as cerebrovascular, glial, and metabolic alterations.•Mct1 haploinsufficient mice are protected from NAFLD and detrimental cerebral alterations.•MCT1 is a potential novel therapeutic target for preventing and/or treating NAFLD and the… Continue reading Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
BackgroundChronic liver diseases of all etiologies exist along a spectrum with varying degrees of hepatic fibrosis. Despite accumulating evidence implying associations between liver fibrosis and cognitive functioning, there is limited research exploring the underlying neurobiological factors and the possible mediating role of inflammation on the liver-brain axis.MethodsUsing data from the UK Biobank, we examined the cross-sectional association… Continue reading Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis
Parkinson’s disease is a progressive neurodegenerative movement disorder with a long latent phase and currently no disease-modifying treatments. Reliable predictive biomarkers that could transform efforts to develop neuroprotective treatments remain to be identified. Using UK Biobank, we investigated the predictive value of accelerometry in identifying prodromal Parkinson’s disease in the general population and compared this… Continue reading Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank
Highlights•Whether daytime napping is causally associated with brain health remains elusive.•We studied the causal role of daytime napping on cognitive and neuroimaging outcomes.•We found a modest causal link between habitual napping and larger total brain volume. Daytime napping has been associated with cognitive function and brain health in observational studies. However, it remains elusive whether these associations… Continue reading Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank
A history of repeated alcohol intoxication promotes cognitive impairment and gene expression signatures of disease progression in the 3xTg mouse model of Alzheimer’s disease
The impact of alcohol abuse on Alzheimer’s disease (AD) is poorly understood. Here, we show that the onset of neurocognitive impairment in a mouse model of AD is hastened by repeated alcohol intoxication through exposure to alcohol vapor, and we provide a comprehensive gene expression dataset of the prefrontal cortex by the single-nucleus RNA sequencing… Continue reading A history of repeated alcohol intoxication promotes cognitive impairment and gene expression signatures of disease progression in the 3xTg mouse model of Alzheimer’s disease
Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
AbstractBackgroundObesity and loss of muscle mass are emerging as risk factors for dementia, but the role of adiposity infiltrating skeletal muscles is less clear. Skeletal muscle adiposity increases with older age and especially among Black women, a segment of the US population who is also at higher risk for dementia.MethodsIn 1634 adults (69–79 years, 48% women,… Continue reading Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults
Nut consumption may reduce age-related cognitive decline, but underlying mechanisms are unclear ObjectiveTo investigate in older adults longer-term effects of mixed nut consumption on brain vascular function, which may underlie improvements in cognitive performance.MethodsTwenty-eight healthy individuals (age [mean ± SD]: 65 ± 3 years; BMI: 27.9 ± 2.3 kg/m2) were included in a randomized, single-blinded, cross-over trial with a 16-week intervention (60 g/d… Continue reading Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults
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