The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear.METHODSWe performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a… Continue reading Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
Category: Neurology
Emotional sounds in space: asymmetrical representation within early-stage auditory areas
Evidence from behavioral studies suggests that the spatial origin of sounds may influence the perception of emotional valence. Using 7T fMRI we have investigated the impact of the categories of sound (vocalizations; non-vocalizations), emotional valence (positive, neutral, negative) and spatial origin (left, center, right) on the encoding in early-stage auditory areas and in the voice… Continue reading Emotional sounds in space: asymmetrical representation within early-stage auditory areas
AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults
BackgroundBody composition data have been limited to adults with disease or older age. The prognostic impact in otherwise asymptomatic adults is unclear.PurposeTo use artificial intelligence–based body composition metrics from routine abdominal CT scans in asymptomatic adults to clarify the association between obesity, liver steatosis, myopenia, and myosteatosis and the risk of mortality. Materials and MethodsIn… Continue reading AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults
Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions… Continue reading Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception
Musicianship can mitigate age-related declines in audiovisual speech-in-noise perception. We tested whether this benefit originates from functional preservation or functional compensation by comparing fMRI responses of older musicians, older nonmusicians, and young nonmusicians identifying noise-masked audiovisual syllables. Older musicians outperformed older nonmusicians and showed comparable performance to young nonmusicians. Notably, older musicians retained similar neural… Continue reading Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception
Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
AbstractBackgroundImpaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and… Continue reading Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
Sex Hormones and Calcitonin Gene–Related Peptide in Women With MigraineA Cross-sectional, Matched Cohort Study
Background and Objectives Sex hormones may modulate calcitonin gene-related peptide (CGRP) release in the trigeminovascular system. We studied CGRP concentrations in plasma and tear fluid in female participants with episodic migraine (EM) and a regular menstrual cycle (RMC), female participants with EM and combined oral contraception (COC), and female participants with EM in the postmenopause.… Continue reading Sex Hormones and Calcitonin Gene–Related Peptide in Women With MigraineA Cross-sectional, Matched Cohort Study
Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
BackgroundOmega-3 fatty acids are critical for neuropsychological functioning. Adolescence is increasingly believed to entail brain vulnerability to dietary intake. The potential benefit on adolescent neurodevelopment of consuming walnuts, a source of omega-3 alpha-linolenic acid (ALA), remains unclear.MethodsWe conducted a 6-month multi-school-based randomised controlled nutrition intervention trial to assess whether walnut consumption has beneficial effects on… Continue reading Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
Migraine Headaches in Patients with Upper Extremity Compressive Neuropathy
Background: Upper extremity nerve compression syndromes and migraines caused by nerve entrapment have many similarities, including patient presentation, anatomical findings, and treatment by surgical decompression of affected nerves. Parallels between the two conditions point toward the possibility of shared predisposition. The aim of this study was to evaluate the relationship between migraine and upper extremity… Continue reading Migraine Headaches in Patients with Upper Extremity Compressive Neuropathy
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