Interventions in preventive cardiology traditionally focus on four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, dyslipidaemia, diabetes mellitus, and smoking. Yet, a substantial proportion of incident cardiovascular events accrues for individuals with none of these factors, particularly among women for whom cardiovascular disease remains under-detected and under-treated. The utility of the inflammatory biomarker high-sensitivity C-reactive… Continue reading #C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
Category: gender
#Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
#Sex and mental #health are related to subcortical #brain microstructure
SignificanceWe demonstrate the presence of large sex-related differences in the microstructure of subcortical gray matter using advanced noninvasive diffusion MRI in a large cohort of young adults. These sex differences are found in several key brain structures that are important for mental health and are consistent with experimental studies in animals showing cellular differences in… Continue reading #Sex and mental #health are related to subcortical #brain microstructure
#Mediterranean #Diet Adherence and Risk of All-Cause #Mortality in #Women
Key PointsQuestion Is adherence to the Mediterranean diet associated with lower mortality in a US female population, and if so, what are possible biological mechanisms? Findings In this cohort study of 25 315 women followed up for 25 years, higher adherence to the Mediterranean diet was associated with a 23% reduced risk of all-cause mortality. Biomarkers of small… Continue reading #Mediterranean #Diet Adherence and Risk of All-Cause #Mortality in #Women
Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
Background/ObjectiveInsulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.Subjects/MethodsAdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis… Continue reading Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder cancer outcomes are notably worse for women than for men. Furthermore, bladder cancer is three to four times more common among men than among women. Factors that might explain these sex differences include understanding the importance of haematuria… Continue reading The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
Dietary #Carbohydrate and #Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
BackgroundPrevious cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.ObjectivesWe examined long-term associations of carbohydrate and fat intakes with mortality.MethodsIn this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014)… Continue reading Dietary #Carbohydrate and #Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
BackgroundPrevious cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.ObjectivesWe examined long-term associations of carbohydrate and fat intakes with mortality.MethodsIn this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014)… Continue reading Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study
Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study
AbstractContextPrevalence of obesity in childhood has increased over the past few decades. The impact of obesity and of obesity-related metabolic disorders on testicular growth is unknown.ObjectiveTo evaluate the impact of obesity, hyperinsulinemia, and insulin resistance on testicular volume (TV) in pre-pubertal (<9 years), peri-pubertal (9-14 years), and post-pubertal (14-16 years) periods.MethodsWe collected data on TV,… Continue reading Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study
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