HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes… Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
Category: Gastroenterology
Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gastrointestinal (GI) toxicity, classifying from acute mucosal damage to GI… Continue reading Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to… Continue reading High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients
This study attempted to screen and combine effective biomarkers to analyse the association between these biomarkers and gastrointestinal failure (GIF) in critically ill patients.Methods: A total of 110 critically ill patients with acute gastrointestinal injury (AGI) admitted to ICU were enrolled. The AGI grade was determined by the AGI classification proposed by ESICM. There were… Continue reading The Serum Citrulline and D-Lactate are Associated with #Gastrointestinal Dysfunction and Failure in Critically #Ill Patients
#Gut-microbiota-targeted #diets modulate human immune status
Diet intervention with systems profiling reveals links in diet-microbiome-immune axis•High-fiber diet changes microbiome function and elicits personalized immune responses•Fermented-food diet increases microbiome diversity and decreases markers of inflammation SummaryDiet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence… Continue reading #Gut-microbiota-targeted #diets modulate human immune status
The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H2S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking. MethodsWe evaluated long-term adherence to the sulfur microbial… Continue reading The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). Participants 116 087 adults aged 35-70 years with… Continue reading Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
Gut #microbiome heritability is nearly universal but environmentally contingent
Baboons inform on human gut microbiotaCommensal bacteria are found throughout an organism, but it is not known whether associations between gut bacteria and their host are heritable. Grieneisen et al. examined changes in the microbiomes of 585 wild baboons from fecal samples collected over 14 years (see the Perspective by Cortes-Ortiz and Amato). Almost all… Continue reading Gut #microbiome heritability is nearly universal but environmentally contingent
SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
Since the late 1980s, global antibiotic consumption and colorectal cancer (CRC) rates in those aged less than 50 years have soared. As the gut microbiome modulates many human processes, significantly altering microbiome structure and diversity with antibiotic therapy has previously been shown to influence CRC genesis in older adults. To our knowledge, no study before… Continue reading SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
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