Patterns of diurnal activity differ substantially between individuals, with early risers and late sleepers being examples of opposite chronotypes. Growing evidence suggests that the late chronotype significantly impacts the risk of developing mood disorders, obesity, diabetes, and other chronic diseases. Despite the vast potential of utilizing chronotype information for precision medicine, those factors that shape… Continue reading Metagenomic analysis reveals the signature of gut microbiota associated with human chronotypes
Category: Gastroenterology
Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseases including Crohn’s disease (CD). Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Here, we report the impact of the interaction between serotonin [5-hydroxytryptamine;(5-HT)] and autophagy in colitis in mouse and human studies. In mice,… Continue reading Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe… Continue reading Genome-wide analysis of 53,400 people with #irritable bowel syndrome highlights shared genetic pathways with #mood and #anxiety disorders
Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical practice. The relationship between serum procalcitonin and CDI in IBD patients has not been investigated so far. Therefore, we aimed to evaluate the usefulness of measuring serum… Continue reading Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Locking down access to the brainInflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al. uncovered a potential pathogenic link between… Continue reading Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Background & AimsMetabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. MethodsThis nationwide cohort study included 8,203,492 adults without cancer who underwent two consecutive biennial health screenings provided… Continue reading Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Fecal #microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits #sleep disturbances in naïve mice
Obstructive sleep apnea (OSA) is a chronic prevalent condition characterized by intermittent hypoxia (IH) and sleep fragmentation (SF). Evidence suggests that OSA can alter the gut microbiome (GM) diversity and composition that may then promote the occurrence of some of the OSA-associated morbidities. However, it is unclear whether perturbations in the GM caused by IH… Continue reading Fecal #microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits #sleep disturbances in naïve mice
Circuit-specific enteric #glia regulate #intestinal motor neurocircuits
Neurons have long been considered the main active cell type within the circuitry of the enteric nervous system (ENS), giving rise to a neurocentric paradigm that has tended to overlook the role of enteric glia as key regulators of gut motility. Understanding how simple synapse-level interactions give rise to complex, network-level behaviors remains a fundamental… Continue reading Circuit-specific enteric #glia regulate #intestinal motor neurocircuits
Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa. MethodsHypertensive… Continue reading Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
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