The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
Category: Gastroenterology
#Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote #behavioral stress resilience
The gut microbiome consists of trillions of bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging from diet changes to illness. Disruption of the community of lactic acid producing bacteria, Lactobaccillacea, has been well documented in mood disorders and stress exposure. In fact, oral supplement with many Lactobacillus species… Continue reading #Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote #behavioral stress resilience
Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and Meta-Analysis
Abstract: Irritable bowel syndrome (IBS) is a highly prevalent disorder of braingut interaction with a significant impact on quality of life. Coffee is a widely consumed beverage with numerous bioactive compounds that have potential effects on human health and disease states. Current studies on the effect of regular coffee consumption on the risk of developing… Continue reading Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and Meta-Analysis
Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency… Continue reading Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
#Proton pump inhibitors and #dementia: A nationwide population-based study
Proton pump inhibitors (PPIs) may increase dementia risk. However, it is currently unknown whether timing of exposure or age at dementia diagnosis influence the risk.METHODSWe assessed associations between cumulative PPI use and dementia at different ages in a nationwide Danish cohort of 1,983,785 individuals aged 60 to 75 years between 2000 and 2018.RESULTSDuring follow-up, there… Continue reading #Proton pump inhibitors and #dementia: A nationwide population-based study
#Prebiotic #diet changes neural correlates of #food decision-making in #overweight adults: a randomised controlled within-subject cross-over trial
Objective Animal studies suggest that prebiotic, plant-derived nutrients could improve homoeostatic and hedonic brain functions through improvements in microbiome–gut–brain communication. However, little is known if these results are applicable to humans. Therefore, we tested the effects of high-dosed prebiotic fibre on reward-related food decision-making in a randomised controlled within-subject cross-over study and assayed potential microbial and… Continue reading #Prebiotic #diet changes neural correlates of #food decision-making in #overweight adults: a randomised controlled within-subject cross-over trial
A two-cohort study on the association between the gut #microbiota and #bone density, microarchitecture, and strength
The gut microbiome affects the inflammatory environment through effects on T-cells, which influence the production of immune mediators and inflammatory cytokines that stimulate osteoclastogenesis and bone loss in mice. However, there are few large human studies of the gut microbiome and skeletal health. We investigated the association between the human gut microbiome and high resolution… Continue reading A two-cohort study on the association between the gut #microbiota and #bone density, microarchitecture, and strength
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients with high-risk colonic polyps are more likely to die from liver related tumors than patients with a negative colonoscopy.MethodsIn this retrospective analysis of mortality data, Austrian screening… Continue reading Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Assessment of Gastroesophageal #Reflux Symptoms and #Sleep Quality Among Women in the Nurses’ Health Study II
Limited data exist on the association of gastroesophageal reflux (GER) symptoms with sleep quality.Objective To prospectively investigate the association between GER symptoms and sleep quality.Design, Setting, and Participants This prospective cohort study included data from the Nurses’ Health Study II of female nurses in the US. Participants self-reported the frequency and duration of GER symptoms beginning June… Continue reading Assessment of Gastroesophageal #Reflux Symptoms and #Sleep Quality Among Women in the Nurses’ Health Study II
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