To assess whether initiation of insulin glargine (glargine), compared with initiation of neutral protamine Hagedorn (NPH) or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes.. Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06)… Continue reading Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
Category: Endocrinology
Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life
To examine the association between age at period cessation and trajectories of anthropometry, blood pressure, lipids and glycated haemoglobin (HbA1c) from midlife to age 69 years.. ..We found no evidence that age at period cessation was associated with trajectories of log triglyceride, LDL-C and HDL-C from 53 to 69 years and trajectories of SBP or… Continue reading Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life
Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study
STUDY OBJECTIVES:Intensive care unit (ICU) nurses commonly work multiple consecutive 12-hr shifts that leave little time for sleep between work shifts. Working multiple consecutive shifts could compromise vigilance and patient care, especially with respect to managing high risk medications such as insulin infusions.. We identified patients who had hypoglycemia (glucose <=3.5mmol/l, 63 mg/dl) between December… Continue reading Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study
Body #mass index, #diabetes, and the risk of #Parkinson’s disease
..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93)… Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease
#Shift Workers at Risk for #Metabolic Syndrome
In this highly digitalized era, sleep disorders are becoming more common and are associated with an increased burden of chronic disease. Shift workers are at an increased risk for both sleep disorders and metabolic syndrome. In this article, the authors outline the connection between circadian discordance, hormonal imbalance, and the development of metabolic syndrome in… Continue reading #Shift Workers at Risk for #Metabolic Syndrome
#Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity
Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice.. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity.. ..We recommend that… Continue reading #Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity
Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism
Patients with hyperthyroidism were excluded from randomized clinical trials of direct oral anticoagulants(DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).. After PSSW, DOAC had a comparable risk of ischemic stroke/systemic embolism (IS/SE) and a lower risk of major bleeding (hazard ratio (HR):0.65; [95% confidential interval (CI):0.44-0.96]; P=0.0295) than warfarin among patients with… Continue reading Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism
#Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
Ultraprocessed foods (UPF) are widespread in Western diets. Their consumption has been associated in recent prospective studies with increased risks of all-cause mortality and chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia; however, data regarding diabetes are lacking. ..Consumption of UPF was associated with a higher risk of T2D (multi-adjusted hazard ratio [HR]… Continue reading #Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
individual patient level data (IPD) ..The odds ratios for myocardial infarction, heart failure, cardiovascular related death, and non-cardiovascular related death were 1.17 (0.92 to 1.51), 1.54 (1.14 to 2.09), 1.15 (0.55 to 2.41), and 1.18 (0.60 to 2.30), respectively. For analyses including trials for which IPD were not available, odds ratios for myocardial infarction and… Continue reading Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
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