Highlights•Migration of > 400 plastic related and > 3500 dishwasher related compounds. •The dishwashing process increased the migration of plastic related compounds. •Oligomers suspected from polycaprolactone (PCL) were migrating. •Three of the identified photoinitiators have possible endocrine disrupting effects. •Diethyltoluamide (DEET) may have been formed from the plasticizer laurolactam. AbstractReusable plastic sports bottles are used… Continue reading Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water
Category: Endocrinology
Evaluation of Adiposity and Cognitive Function in Adults
Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association… Continue reading Evaluation of Adiposity and Cognitive Function in Adults
Adipogenic Activity of Chemicals Used in Plastic Consumer Products
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in cell and animal models. However, these well-known metabolism-disrupting chemicals (MDCs) represent only a minute fraction of all compounds found in plastics. To gain a comprehensive understanding of plastics as a source of exposure to MDCs, we characterized the chemicals present in 34 everyday… Continue reading Adipogenic Activity of Chemicals Used in Plastic Consumer Products
Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Diabetes mellitus is an independent risk factor for atrial fibrillation or atrial flutter (atrial arrythmia, AA). Additionally, some diabetes medications may influence AA incidence. The aim of this post hoc analysis was to assess the occurrence of AA during the study period in patients with type 2 diabetes treated with once weekly subcutaneous dulaglutide vs… Continue reading Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
Highlights1)Thyrotoxicosis with palpitation, and neck tenderness is the most common presentation of thyroiditis. The patients with new onset of thyrotoxicosis should be asked about history of mRNA-vaccine injection for the possible etiology. 2)mRNA vaccine induced thyroiditis could occur 10-20 days after the first dose or the second dose. 3)Management is to relieve the symptom of… Continue reading Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
FGF1 and insulin control lipolysis by convergent pathways
Highlights•FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production•FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation•Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia•FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states SummaryInexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously,… Continue reading FGF1 and insulin control lipolysis by convergent pathways
Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)
Hypoglycemia induced by direct-acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life-threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs. MethodsReports to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1… Continue reading Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)
Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Type 2 Diabetes is a metabolic disorder characterized by hyperglycemia that causes numerous complications with significant long-term morbidity and mortality. The disorder is primarily due to insulin resistance particularly in liver, skeletal muscle, and adipose tissue. In this review, we detail the hormonal mechanisms leading to the development of diabetes and discuss whether intermittent fasting… Continue reading Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians
Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study
Background:It is unknown whether the risk of thyroid cancer differs among metabolically healthy/unhealthy, normal-weight, or obese women. We aimed to assess the association of metabolic health and obesity with thyroid cancer risk. Methods:The Korean Genome and Epidemiology Study is a population-based prospective cohort study. Data were obtained from 173,343 participants (age {greater than or equal… Continue reading Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study
