Screening, diagnosing, and managing hypothyroidism: ATA/AACE guidelines recommend screening for all patients with symptoms of hypothyroidism. For patients whoare asymptomatic, recommendations vary widely. However, a thyroid-stimulating hormone (TSH) test is generallyrecommended for patients ≥50–60 years old, especially women. Guidelines also state that there is compelling evidence to support screening in patients with: Hypothyroidism: algorithm for… Continue reading Hypo- and hyper- #thyroidism: algorithm for screening and diagnosis
Category: Endocrinology
#Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Objective To investigate the association between walking speed and the risk of type 2 diabetes.Design Systematic review and meta-analysis.Data sources PubMed, Scopus, CENTRAL and Web of Science to 30 May 2023.Eligibility criteria for selecting studies We included cohort studies that explored the association between walking speed and the risk of type 2 diabetes in adults. We used random-effects meta-analyses… Continue reading #Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but it is unclear how family history may be used to identify first-degree relatives with advanced fibrosis. We aimed to develop and validate a simple risk score to identify first-degree relatives of probands who have undergone assessment of liver fibrosis who are at higher risk of NAFLD… Continue reading Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
#Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Objective To investigate the association between walking speed and the risk of type 2 diabetes.Design Systematic review and meta-analysis.Data sources PubMed, Scopus, CENTRAL and Web of Science to 30 May 2023.Eligibility criteria for selecting studies We included cohort studies that explored the association between walking speed and the risk of type 2 diabetes in adults. We used random-effects meta-analyses… Continue reading #Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Lower serum #testosterone is associated with increased likelihood of #arthritis
Studies have suggested that serum testosterone levels may be strongly correlated with the pathogenesis of arthritis. Therefore, the aim of this study was to assess the relationship between serum testosterone levels and arthritis in US adults using the National Health and Nutrition Examination Survey (NHANES). We used the database from NHANES, 2013–2016 to perform a… Continue reading Lower serum #testosterone is associated with increased likelihood of #arthritis
Associations between Metabolomic Biomarkers of #Avocado Intake and #Glycemia in the Multi-Ethnic Study of Atherosclerosis
BackgroundAvocado consumption is linked to better glucose homeostasis, but small associations suggest potential population heterogeneity. Metabolomic data capture the effects of food intake after digestion and metabolism, thus accounting for individual differences in these processes.ObjectivesTo identify metabolomic biomarkers of avocado intake and to examine their associations with glycemia.MethodsBaseline data from 6224 multi-ethnic older adults (62% female) included self-reported avocado… Continue reading Associations between Metabolomic Biomarkers of #Avocado Intake and #Glycemia in the Multi-Ethnic Study of Atherosclerosis
Dietary #Sodium Intake and Risk of Incident Type 2 #Diabetes
ObjectiveTo fill the knowledge gap of the relation between long-term dietary sodium intake and type 2 diabetes (T2D), we evaluate the association between the frequency of adding salt to foods, a surrogate marker for evaluating the long-term sodium intake, and incident T2D risk.MethodsA total of 402,982 participants from UK Biobank (March 13, 2006 – October… Continue reading Dietary #Sodium Intake and Risk of Incident Type 2 #Diabetes
Designing and computational analyzing of chimeric long-lasting #GLP-1 receptor agonists for type 2 #diabetes
Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1–2 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question. Since albumin-binding DARPin as a mimetic molecule has been reported to… Continue reading Designing and computational analyzing of chimeric long-lasting #GLP-1 receptor agonists for type 2 #diabetes
Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Tea and coffee are the most consumed beverages worldwide and very often sweetened with sugar. However, the association between the use of sugar in tea or coffee and adverse events is currently unclear.ObjectivesTo investigate the association between the addition of sugar to coffee or tea, and the risk of all-cause mortality, cardiovascular mortality, cancer mortality… Continue reading Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
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