ObjectiveTo fill the knowledge gap of the relation between long-term dietary sodium intake and type 2 diabetes (T2D), we evaluate the association between the frequency of adding salt to foods, a surrogate marker for evaluating the long-term sodium intake, and incident T2D risk.MethodsA total of 402,982 participants from UK Biobank (March 13, 2006 – October… Continue reading Dietary #Sodium Intake and Risk of Incident Type 2 #Diabetes
Category: Endocrinology
Designing and computational analyzing of chimeric long-lasting #GLP-1 receptor agonists for type 2 #diabetes
Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1–2 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question. Since albumin-binding DARPin as a mimetic molecule has been reported to… Continue reading Designing and computational analyzing of chimeric long-lasting #GLP-1 receptor agonists for type 2 #diabetes
Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Tea and coffee are the most consumed beverages worldwide and very often sweetened with sugar. However, the association between the use of sugar in tea or coffee and adverse events is currently unclear.ObjectivesTo investigate the association between the addition of sugar to coffee or tea, and the risk of all-cause mortality, cardiovascular mortality, cancer mortality… Continue reading Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Changes in #Coffee Intake, Added #Sugar and Long-Term #Weight Gain – Results from Three Large Prospective US Cohort Studies
BackgroundConsumption of both caffeinated and decaffeinated coffee has been reported to attenuate long-term weight gain. Whether the association between coffee consumption and weight gain depends on the addition of sugar, cream or coffee whitener remains unclear.ObjectiveWe aimed to study the associations between changes in coffee consumption, caffeine intake and weight changes by considering the addition… Continue reading Changes in #Coffee Intake, Added #Sugar and Long-Term #Weight Gain – Results from Three Large Prospective US Cohort Studies
Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
Background Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes.MethodsIn this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes… Continue reading Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
#Semaglutide in Early Type 1 #Diabetes
In this small case series, semaglutide after the diagnosis of type 1 diabetes led to elimination of prandial insulin in all patients and basal insulin in most, along with improved glycemic control. https://www.nejm.org/doi/full/10.1056/NEJMc2302677
Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
BackgroundAssociations of weight changes and intentionality of weight loss with longevity are not well described.MethodsUsing longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10,… Continue reading Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
Long-term #cancer outcomes after #bariatric surgery
ObjectiveObesity is associated with increased cancer risk. Because of the substantial and sustained weight loss following bariatric surgery, postsurgical patients are ideal to study the association of weight loss and cancer.MethodsRetrospectively (1982–2019), 21,837 bariatric surgery patients (surgery, 1982–2018) were matched 1:1 by age, sex, and BMI with a nonsurgical comparison group. Procedures included gastric bypass,… Continue reading Long-term #cancer outcomes after #bariatric surgery
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