Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40–70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl−1, rising by 0.234 mg dl−1 per year with… Continue reading Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
Category: Endocrinology
In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
Globaplastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals… Continue reading In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.Objective To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.Design, Setting, and Participants This large-scale,… Continue reading #Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.Key Facts:Molecular… Continue reading Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
Background and aims Obesity and overweight have become significant health concerns worldwide, leading to an increased interest in finding natural remedies for weight reduction. One such remedy that has gained popularity is apple cider vinegar (ACV).Objective To investigate the effects of ACV consumption on weight, blood glucose, triglyceride and cholesterol levels in a sample of the Lebanese… Continue reading Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Tobacco exposure in adulthood is a well-established risk factor for type 2 diabetes (T2D), but how early-life tobacco exposure implicates in the development of T2D as well as whether this association varies by different genetic predisposition to T2D are unclear. Addressing these gaps may provide novel insights into early interventions of T2D.Hypothesis We hypothesized that tobacco… Continue reading 30 – Early-Life #Tobacco Exposure, Genetic Risk, and Incident Type 2 #Diabetes
Lac-Phe mediates the effects of #metformin on #food intake and body weight
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalanine (Lac-Phe) in cells, in mice and two independent human cohorts. Metformin drives Lac-Phe biosynthesis through… Continue reading Lac-Phe mediates the effects of #metformin on #food intake and body weight
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
BackgroundThere is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
