For decades, vitamin #D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with respect to fracture and fall prevention in vitamin D-replete populations. Moreover, growing evidence suggesting an increased fall risk associated with highdose bolus administration has… Continue reading Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials
Category: Diet
Female Underweight/Undernutrition Syndrome (FUS): An Emerging Health Concept in Premenopausal Women – Secondary Publication (English Translation of the Japanese Statement)
In Japan, approximately 20% of women in their twenties are #underweight (BMI < 18.5 kg/m2), representing one of the highest prevalences among developed nations. Underweight and undernutrition are associated with decreased bone mass, menstrual abnormalities, impaired glucose tolerance, sarcopenia-like changes, and systemic symptoms including depression and fatigue, significantly impacting health from young adulthood through the… Continue reading Female Underweight/Undernutrition Syndrome (FUS): An Emerging Health Concept in Premenopausal Women – Secondary Publication (English Translation of the Japanese Statement)
Comparison of nutrients and ultra-processed food consumption between different phenotypes defined by abdominal obesity and sarcopenia
Background: #Obesity, #sarcopenia, and sarcopenic obesity require effective nutritional strategies in public health.Methods: This cross-sectional study analyzed 535 adults aged 40–60 years in rural Korea. Participants were grouped by abdominal obesity (waist circumference ≥90 cm for men, ≥85 cm for women) and probable sarcopenia (handgrip strength ≤28 kg for men, ≤18 kg for women). Dietary intake was assessed using a… Continue reading Comparison of nutrients and ultra-processed food consumption between different phenotypes defined by abdominal obesity and sarcopenia
#Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
The effects of glucagon-like peptide-1 receptor agonists (#GLP1-RAs ) on #alcohol -related outcomes: a systematic review and meta-analysis
Objective: To evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on alcohol-related outcomes in adults with or without alcohol use disorder (AUD).Methods: A systematic review and meta-analysis following PRISMA guidelines searched PubMed, Embase, and Cochrane Library up to May 3, 2025. Eligible studies included randomized controlled trials (RCTs) and observational studies assessing GLP-1RAs (e.g.,… Continue reading The effects of glucagon-like peptide-1 receptor agonists (#GLP1-RAs ) on #alcohol -related outcomes: a systematic review and meta-analysis
#Ultra-processed foods and human health: the main thesis and the evidence
This first paper in a three-part Lancet Series combines narrative and systematic reviews with original analyses and meta-analyses to assess three hypotheses concerning a dietary pattern based on ultra-processed foods. The first hypothesis—that this pattern is globally displacing long-established diets centred on whole foods and their culinary preparation as dishes and meals—is supported by decades… Continue reading #Ultra-processed foods and human health: the main thesis and the evidence
Alcohol’s Effects on the Lung and Lung Disease
Purpose: Alcohol misuse is widely accepted as an independent risk factor for a wide variety of lung diseases, such as pneumonia and acute respiratory distress syndrome. Alcohol induces changes in the regulatory mechanisms of the lung, both at a mechanical and immunological level. Understanding these changes might help discover new targets for drugs and therapeutic… Continue reading Alcohol’s Effects on the Lung and Lung Disease
#Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Key PointsQuestion Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?Findings In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with… Continue reading Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
