Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality

We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and … Continue reading Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality

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Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to … Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

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#Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants

Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role. Meat consumption has been cross-sectionally associated with dementia risk, but specific amounts and types related to risk of incident dementia remain poorly understood. Objective We aimed to investigate associations between meat consumption and risk of incident dementia in the UK Biobank cohort. Methods Meat consumption was estimated using … Continue reading #Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants

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#Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?

There is evidence that caffeine increases the maximal fat oxidation rate (MFO) and aerobic capacity, which are known to be lower in the morning than in the afternoon. This paper examines the effect of caffeine intake on the diurnal variation of MFO during a graded exercise test in active men. Methods Using a triple-blind, placebo-controlled, crossover experimental design, 15 active caffeine-naïve men (age: 32 ± 7 years) completed … Continue reading #Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?

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Association Between Maternal #Caffeine Consumption and Metabolism and Neonatal Anthropometry

Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. Objective To evaluate the association between maternal caffeine intake and neonatal anthropometry, testing effect modification by fast or slow caffeine metabolism genotype. … Continue reading Association Between Maternal #Caffeine Consumption and Metabolism and Neonatal Anthropometry

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Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease

Alcohol-associated liver disease represents a spectrum of histopathological changes from steatosis to advanced fibrosis and cirrhosis. The major goals of this retrospective study were to characterize the histologic features in patients with excessive alcohol use who presented with an abnormal hepatic panel and/or abnormal radiographic imaging and did not meet the clinical diagnosis of alcoholic hepatitis or cirrhosis. Methods We performed a retrospective study to … Continue reading Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease

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#Semaglutide 2·4 mg once a week in adults with #overweight or #obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Background This trial assessed the efficacy and safety of the GLP-1 analogue once a week subcutaneous semaglutide 2·4 mg versus semaglutide 1·0 mg (the dose approved for diabetes treatment) and placebo for weight management in adults with overweight or obesity, and type 2 diabetes. Methods This double-blind, double-dummy, phase 3, superiority study enrolled adults with a body-mass index of at least 27 kg/m2 and glycated … Continue reading #Semaglutide 2·4 mg once a week in adults with #overweight or #obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

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The Value of Total #Knee Replacement in Patients With Knee #Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater A Cost-Effectiveness Analysis

Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of 40 kg/m2 or greater has raised concerns about the value of TKR in this population. Objective: To assess the value of TKR in recipients with a BMI of 40 kg/m2 or greater using a cost-effectiveness analysis. … Continue reading The Value of Total #Knee Replacement in Patients With Knee #Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater A Cost-Effectiveness Analysis

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Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation

Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized trial data are lacking. Objective To test the effects of … Continue reading Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation

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Fructose- and sucrose- but not glucose-sweetened #beverages promote hepatic de novo #lipogenesis: A randomized controlled trial

Excessive fructose intake associates with increased de novo lipogenesis, blood triglycerides, and hepatic insulin resistance. Whether fructose-specific effects on lipid metabolism in healthy men exist independently from overfeeding needs clarification. Methods 94 subjects were studied in this double-blind, randomized trial. They were assigned to daily consumption of sugar-sweetened beverages (SSB) containing moderate amounts of fructose, sucrose (fructose-glucose disaccharide) or glucose (80g/day) in addition to their … Continue reading Fructose- and sucrose- but not glucose-sweetened #beverages promote hepatic de novo #lipogenesis: A randomized controlled trial

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Circulating Vitamin #D levels status and clinical prognostic indices in #COVID-19 patients

Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. Methods Lymphocyte phenotypes were assessed by … Continue reading Circulating Vitamin #D levels status and clinical prognostic indices in #COVID-19 patients

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KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea

Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecular mechanisms of action. The KCNQ5 voltage-gated potassium channel contributes to vascular smooth muscle tone and neuronal M-current regulation. Methods: We applied electrophysiology, myography, mass spectrometry and in silico docking to determine effects and their underlying … Continue reading KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea

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