Vitamin #D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capacity, decreased lean mass, and increased adiposity. Here, we examine if VitD insufficiency results in similar deficits and greater frailty progression in old-aged (24 to 28 months of age) … Continue reading Vitamin #D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

Effect of Vitamin #D and ω-3 #Fatty Acid Supplementation on Risk of Age-Related #Macular Degeneration An Ancillary Study of the VITAL Randomized Clinical Trial

Observational studies suggest that higher intake or blood levels of vitamin D and marine ω-3 fatty acids may be associated with lower risks of age-related macular degeneration (AMD). However, evidence from randomized trials is limited.. ..In total, 25 871 participants with a mean (SD) age of 67.1 (7.0) years were included in the trial. Of them, 50.6% were women, 71.3% were self-declared non-Hispanic White participants, and … Continue reading Effect of Vitamin #D and ω-3 #Fatty Acid Supplementation on Risk of Age-Related #Macular Degeneration An Ancillary Study of the VITAL Randomized Clinical Trial

Air #pollution as a determinant of food delivery and related #plastic waste

Plastic waste is a growing environmental concern. The food delivery industry is criticized for its environmental impact, especially its current use of plastic packaging. At the same time, the environment impacts the industry. We show that air pollution is a behavioural driver of food delivery consumption in the urban developing world. Our hypothesis is that individuals are more likely to order delivery when their personal … Continue reading Air #pollution as a determinant of food delivery and related #plastic waste

Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease

In general, physical activity (PA) and nonalcoholic fatty liver disease (NAFLD) have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans (PA Guidelines) on NAFLD are lacking. We performed a serial, cross‐sectional analysis among adults by using the 2007‐2016 US National Health and Nutrition Examination Survey. NAFLD and advanced fibrosis were defined by using various noninvasive panels. … Continue reading Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease

Additive effects of green #tea and #coffee on all-cause mortality in patients with type 2 #diabetes mellitus: the Fukuoka Diabetes Registry

The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.. ..During the follow-up period, 309 participants died. The consumption of green tea, coffee, and a combination of the beverages was associated with reduced all-cause mortality. Multivariable-adjusted hazard ratios (95% … Continue reading Additive effects of green #tea and #coffee on all-cause mortality in patients with type 2 #diabetes mellitus: the Fukuoka Diabetes Registry

#Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.. ..In total, 2007 and 2040 patients were included in the surgery group and the control group, respectively, and 1135 participants were included in the reference cohort. At the time of the analysis (December 31, 2018), the median duration of follow-up for … Continue reading #Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD. ..The TyG index was significantly correlated with the severity of hepatic steatosis and the presence of liver fibrosis in patients with NAFLD. TyG quartile values … Continue reading The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences–National … Continue reading Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Prevalence and Prognostic Significance of #Malnutrition in Patients With Acute #Coronary Syndrome

Malnutrition is associated with poor prognosis in a wide range of illnesses. However, its prognostic impact in patients with acute coronary syndrome (ACS) is not well known.. ..In this study, the Controlling Nutritional Status (CONUT) score, the Nutritional Risk Index (NRI), and the Prognostic Nutritional Index (PNI) was applied to 5,062 consecutive patients with ACS. The relationships between malnutrition risk and all-cause mortality and major … Continue reading Prevalence and Prognostic Significance of #Malnutrition in Patients With Acute #Coronary Syndrome

Dietary #Fructose Alters the Composition, Localization and Metabolism of Gut #Microbiota in Association with Worsening #Colitis

The incidence of inflammatory bowel diseases has increased over the last half century, suggesting a role for dietary factors. Fructose consumption has increased in recent years. Recently, a high fructose diet (HFrD) was shown to enhance DSS-induced colitis in mice. The primary objectives of the current study were to elucidate the mechanism(s) underlying the pro-colitic effects of dietary fructose and to determine whether this effect … Continue reading Dietary #Fructose Alters the Composition, Localization and Metabolism of Gut #Microbiota in Association with Worsening #Colitis

Cognitive Factors Associated with Frequency of #Eating Out and Eating Takeout among Latinas

Higher frequency of eating outside the home can be an unhealthy behavior that may contribute to higher rates of obesity among Latinas, a disproportionately affected group. There is a growing need to understand potentially modifiable factors (eg, dispositional mindfulness, self-efficacy, nutrition knowledge) associated with higher frequency of eating outside the home in this population. This study assessed associations of cognitive factors (ie, dispositional mindfulness, self-efficacy … Continue reading Cognitive Factors Associated with Frequency of #Eating Out and Eating Takeout among Latinas

#ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019

Aspirin has been associated to a reduced risk of colorectal and other selected digestive tract cancers, but the evidence other neoplasms is still controversial. In order to provide an up‐to‐date quantification of the role of aspirin on lung, breast, endometrium, ovary, prostate, bladder, and kidney cancer, we conducted a systematic review and meta‐analysis of all observational studies published up to March 2019. We estimated pooled … Continue reading #ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019