This study sought to characterize cognitive decline (CD) over time and its predictors in patients with systolic heart failure (HF) ..In logistic regression, CD was independently associated with higher baseline MMSE scores (odds ratio [OR]: 1.13; 95% confidence interval [CI]: 1.07 to 1.20]; p < 0.001), older age (OR: 1.37; 95% CI: 1.24 to 1.50;… Continue reading #Cognitive Decline Over Time in Patients With Systolic #Heart Failure Insights From WARCEF
Category: Cardiology
#Dapagliflozin in Patients with Heart Failure and Reduced #Ejection Fraction
In patients with type 2 diabetes, inhibitors of sodium–glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms.. A first worsening heart failure event occurred in 237 patients (10.0%) in the dapagliflozin group and in 326 patients (13.7%) in the placebo group (hazard ratio, 0.70; 95% CI,… Continue reading #Dapagliflozin in Patients with Heart Failure and Reduced #Ejection Fraction
Altered Risk for #cardiovascular Events With Changes in the #Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons
Population-scale evidence for the association between dynamic changes in metabolic syndrome (MetS) status and alterations in the risk for major adverse cardiovascular events (MACE) is lacking ..At a median follow-up of 3.54 years, the MetS-recovery group (incidence rate, 4.55 per 1000 person-years) had a significantly lower MACE risk (adjusted IRR, 0.85 [95% CI, 0.83 to… Continue reading Altered Risk for #cardiovascular Events With Changes in the #Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons
Association of #troponin level and age with #mortality in 250 000 patients: cohort study across five UK acute care centres
.. A positive troponin result (that is, higher than the upper limit of normal) signified a 3.2 higher mortality hazard (95% confidence interval 3.1 to 3.2) over three years. Mortality varied noticeably with age, with a hazard ratio of 10.6 (8.5 to 13.3) in 18-29 year olds and 1.5 (1.4 to 1.6) in those older… Continue reading Association of #troponin level and age with #mortality in 250 000 patients: cohort study across five UK acute care centres
Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated that a systolic blood pressure (BP) target less than 120 mm Hg was superior to less than 140 mm Hg for preventing vascular events. This trial excluded patients with prior stroke; therefore, the ideal BP target for secondary stroke prevention remains unknown. ..Throughout the overall follow-up period,… Continue reading Effect of Standard vs Intensive Blood #Pressure Control on the Risk of Recurrent #Stroke
Taller people have increased risk for developing atrial #fibrillation
Researchers found that the risk for AFib climbed as one's height increased, with every one-inch increase in height translating to about a three percent increase in risk of Afib--independent of other clinical factors--as compared to those at average height (5 feet and 7 inches). "Our findings suggest it may be beneficial to incorporate height into… Continue reading Taller people have increased risk for developing atrial #fibrillation
#Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
..major adverse cardiovascular events (MACE) ..Aspirin use did not translate into a net clinical benefit adjusted for event-associated mortality risk (mean 0.034%; 95% CI, − 0.18 to 0.25%). There was an interaction for aspirin effect in three patient subgroups: (i) in patients under statin treatment, aspirin was associated with a 12% RRR of MACE (RR 0.88;… Continue reading #Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups
Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent
..There was a highly non-trivial dependence of statin dosage with the ORs of osteoporosis. Osteoporosis was underrepresented in low-dose statin treatment (0–10 mg per day), including lovastatin (OR: 0.39, CI 0.18 to 0.84, p<0.05), pravastatin (OR: 0.68, 95% CI 0.52 to 0.89, p<0.01), simvastatin (OR: 0.70, 95% CI 0.56 to 0.86, p<0.01) and rosuvastatin (OR: 0.69, 95% CI 0.55… Continue reading Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent
Specific #jobs linked to poor #heart health for women
..Compared to women in other occupations: Social workers were 36% more likely to have poor heart health. Retail cashiers were 33% more likely to have poor heart health. Women in some health care roles were up to 16% more likely to have poor heart health, especially in the areas of nursing and psychiatry and home… Continue reading Specific #jobs linked to poor #heart health for women
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