Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Category: Cardiology
Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Psychosocial stress (PSS) is a significant contributor of inflammation and CVD.• NLRP3 inflammasome activation amplifies inflammation in response to PSS.• ER stress is a key upstream mechanism that triggers NLRP3 inflammasome activation.• This study reveals mechanisms and targets to reduce inflammation caused by PSS. AbstractPsychosocial stress (PSS) affects all humans with different intensities and is… Continue reading Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
Question Is the incidence or outcome of out-of-hospital cardiac arrest (OHCA) changing over time overall or among important demographic or clinical groups?Findings In this cohort study including 25 118 individuals, temporal incidence patterns depended on rhythm and demographic characteristics, with some groups experiencing decrease, some increase, and others no change. In contrast, OHCA outcomes improved over… Continue reading Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood #Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice #Guidelines
The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.”METHODS:A comprehensive literature search was conducted from December 2023 to June 2024 to identify clinical studies, reviews, and other… Continue reading 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood #Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice #Guidelines
Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
To examine the dose-response associations of step count and stepping intensity with risk of cardiovascular mortality and incidence of heart failure (HF), myocardial infarction (MI), and stroke (major adverse cardiovascular events, MACE) in people with hypertension.Methods and resultsData were obtained from participants with established hypertension from the UK Biobank accelerometry sub-study. Participants wore a wrist-worn… Continue reading Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored.Objective To evaluate MVPA trajectories across adulthood, pre-CVD and post-CVD changes, and demographic variations.Design, Setting, and Participants Data were drawn from CARDIA (Coronary Artery Risk Development in Young Adults), a… Continue reading Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
#PREVENT Risk Age Equations and Population Distribution in US #Adults
Current US guidelines recommend absolute risk estimation of cardiovascular disease (CVD) to guide decisions on preventive therapies, but communicating absolute risk alone can be challenging for patients and clinicians.1 In 2021, the European Society of Cardiology guidelines added a recommendation to calculate risk age along with absolute risk to improve communication.2 Risk age represents the… Continue reading #PREVENT Risk Age Equations and Population Distribution in US #Adults
Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
BackgroundDespite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outcomes, mental health outcomes,… Continue reading Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
Health effects associated with consumption of #processed #meat, #sugar -sweetened beverages and trans #fatty acids: a Burden of Proof study
Previous research suggests detrimental health effects associated with consuming processed foods, including processed meats, sugar-sweetened beverages (SSBs) and trans fatty acids (TFAs). However, systematic characterization of the dose–response relationships between these foods and health outcomes is limited. Here, using Burden of Proof meta-regression methods, we evaluated the associations between processed meat, SSBs and TFAs and… Continue reading Health effects associated with consumption of #processed #meat, #sugar -sweetened beverages and trans #fatty acids: a Burden of Proof study
2 Medical News 