Backg round: Hysterectomy, oophorectomy, and tubal ligation are common surgical procedures. The literature regarding cardiovascular disease (CVD) risk after these surgeries has focused on oophorectomy with limited research on hysterectomy or tubal ligation.Materials and Methods: Participants in the Nurses' Health Study II (n = 116,429) were followed from 1989 to 2017. Self-reported gynecologic surgery was categorized as follows: no… Continue reading Hysterectomy With and Without Oophorectomy, Tubal Ligation, and Risk of Cardiovascular Disease in the Nurses’ Health Study II
Category: Cardiology
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Background:Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys and VSMCs and uncovered relevant sEV-propagated microRNAs (miRNAs) and their biological signaling pathways.Methods and Results:We established CKD models in rats and mice by adenine-induced tubulointerstitial fibrosis.… Continue reading Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD).Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish… Continue reading Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study
Objective To investigate the intake of specific types of beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 diabetes.Design Prospective cohort study.Setting Health professionals in the United States.Participants 15 486 men and women with a diagnosis of type 2 diabetes at baseline and during follow-up (Nurses’ Health Study: 1980-2018; and… Continue reading Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study
Association of Rurality With Risk of Heart Failure
Rural populations experience an increased burden of heart failure (HF) mortality compared with urban populations. Whether HF incidence is greater among rural individuals is less known. Additionally, the intersection between racial and rural health inequities is understudied.Objective To determine whether rurality is associated with increased risk of HF, independent of cardiovascular (CV) disease and socioeconomic… Continue reading Association of Rurality With Risk of Heart Failure
SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Exclusion of the left atrial appendage to reduce thromboembolic risk related to atrial fibrillation was first performed surgically in 1949. Over the past 2 decades, the field of transcatheter endovascular left atrial appendage closure (LAAC) has rapidly expanded, with a myriad of devices approved or in clinical development. The number of LAAC procedures performed in… Continue reading SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Association of Daily Step Patterns With Mortality in US Adults
Importance Previous studies have shown that individuals who regularly walk, particularly 8000 daily steps or more, experience lower mortality. However, little is known about the health benefits of walking intensively only a few days a week.Objective To evaluate the dose-response association between the number of days an individual takes 8000 steps or more and mortality… Continue reading Association of Daily Step Patterns With Mortality in US Adults
Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
Background:Coronary atherosclerosis may develop at an early age and remain latent for many years.Objective:To define characteristics of subclinical coronary atherosclerosis associated with the development of myocardial infarction.Design:Prospective observational cohort study.Setting:Copenhagen General Population Study, Denmark.Participants:9533 asymptomatic persons aged 40 years or older without known ischemic heart disease.Measurements:Subclinical coronary atherosclerosis was assessed with coronary computed tomography angiography… Continue reading Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.Objective To determine whether torsemide results in decreased mortality compared with furosemide among patients hospitalized for heart failure.Design, Setting, and Participants TRANSFORM-HF was an open-label, pragmatic randomized trial that recruited 2859 participants hospitalized with… Continue reading Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
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