Aim: Some observational studies have observed a lower, rather than higher, mortality rate in association with hypercholesterolemia during follow-up of patients after cardiac stress testing. We aim to assess the relationship of hypercholesterolemia and other CAD risk factors to mortality across a wide spectrum of patients referred for various cardiac tests.Methods and results: We identified four cardiac… Continue reading Association between hypercholesterolemia and mortality risk among patients referred for cardiac imaging test: Evidence of a “cholesterol paradox?”
Author: aledopress
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SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
Background: Both natural immunity and vaccine-induced immunity to COVID-19 may be useful to reduce the mortality/morbidity of this disease, but still a lot of controversy exists. Aims: This narrative review analyzes the literature regarding these two immunitary processes and more specifically: (a) the duration of natural immunity; (b) cellular immunity; (c) cross-reactivity; (d) the duration… Continue reading SARS-CoV-2—The Role of Natural Immunity: A Narrative Review
A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial
Objective Postmenopausal vasomotor symptoms disrupt quality of life. This study tested the effects of a dietary intervention on vasomotor symptoms and menopause-related quality of life.Methods Postmenopausal women (n = 84) reporting at least two moderate-to-severe hot flashes daily were randomly assigned, in two successive cohorts, to an intervention including a low-fat, vegan diet and cooked soybeans (½ cup [86… Continue reading A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial
Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department
Importance For patients discharged from the emergency department (ED), timely outpatient in-person follow-up is associated with improved mortality, but the effectiveness of telehealth as follow-up modality is unknown.Objective To evaluate whether the rates of ED return visits and hospitalization differ between patients who obtain in-person vs telehealth encounters for post-ED follow-up care.Design, Setting, and Participants This retrospective cohort… Continue reading Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department
Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants
BACKGROUNDTo investigate the associations between courses of depression, the application of depression treatment, and the risk of incident dementia.METHODSIn this prospective cohort study, 354,313 participants aged 50 to 70 years were recruited from the UK Biobank between 2006 and 2010, and were followed-up until 2020, with a total of 4,212,929 person-years. We initially studied the… Continue reading Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants
Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
Metal ions present in cellular microenvironment have been implicated as drivers of aggregation of amyloid forming proteins. Zinc (Zn2+) ions have been reported to directly interact with α-synuclein (AS), a causative agent of Parkinson's disease and other neurodegenerative diseases, and promote its aggregation. AS is a small intrinsically disordered protein (IDP) i.e., understanding molecular factors… Continue reading Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
The Cost of Inaction on Physical Inactivity to Healthcare Systems
Background: Physical inactivity (PI) is an important modifiable risk factor for noncommunicable diseases (NCDs) and mental health conditions. Estimating the public healthcare costs associated with these diseases due to PI will help policymakers to prioritise investment in policy actions to promote and enable more people to be more active.Methods: We used a population attributable fraction… Continue reading The Cost of Inaction on Physical Inactivity to Healthcare Systems
Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
AbstractObjectiveThe purpose of this study was to identify the prevalence of severe headache or migraine and the association between dietary thiamine and riboflavin intake with headache history using a large, nationally representative population sample.BackgroundSevere headache and migraine are common and disabling neurological disorders worldwide. Previous studies revealed that the B vitamin group, as an important… Continue reading Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan
Current countermeasures for preventing hypertension emphasize only improvements to lifestyle. Recently, improving life environment has attracted attention, in parallel with publication of the WHO Housing and health guidelines. We quantitatively evaluated the relationship between housing thermal environment and blood pressure (BP) in a real-world setting. We conducted a nationwide, prospective intervention study—the Smart Wellness Housing… Continue reading Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan
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